Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy

被引：148

作者：

Sommer, C ^{[1
]}

Petrausch, S ^{[1
]}

Lindenlaub, T ^{[1
]}

Toyka, KV ^{[1
]}

机构：

[1] Univ Wurzburg, Neurol Klin, D-97080 Wurzburg, Germany

来源：

NEUROSCIENCE LETTERS | 1999年 / 270卷 / 01期

关键词：

hyperalgesia; neuropathy; cytokines; interleukin-1-receptor; tumor necrosis factor-alpha;

D O I：

10.1016/S0304-3940(99)00450-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated whether interieukin-1 (IL-1), a mediator of inflammatory pain, also plays a role in pain induced by nerve injury. Female C57BL/6-mice with a chronic constrictive injury of one sciatic nerve, an established model of neurogenic hyperalgesia and allodynia, were treated with different doses (10-80 mu g) of a neutralizing monoclonal rat antibody to IL-1 receptor I (anti-IL-1RI). This antibody dose-dependently reduced thermal hyperalgesia and mechanical allodynia in the animals. Furthermore, immunoreactivity for the proinflammatory cytokine tumor necrosis factor-a (INF) was reduced in mice treated with the highest dose of anti-IL-1RI. Degeneration of myelinated fibers was not altered by any of the treatment schedules. We conclude that IL-1 may be a mediator of hyperalgesia after nerve lesion. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：25 / 28

页数：4

共 23 条

[1] A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN [J].