Anthraquinone derivatives from the mangrove-derived fungus Phomopsis sp PSU-MA214

被引：29

作者：

Klaiklay, Saranyoo ^{[1
,2
]}

Rukachaisirikul, Vatcharin ^{[1
,2
]}

Phongpaichit, Souwalak ^{[3
,4
]}

Pakawatchai, Chaveng ^{[1
,2
]}

Saithong, Saowanit ^{[1
,2
]}

Buatong, Jirayu ^{[3
,4
]}

Preedanon, Sita ^{[5
]}

Sakayaroj, Jariya ^{[5
]}

机构：

[1] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand

[2] Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Songkhla, Thailand

[3] Prince Songkla Univ, Fac Sci, Nat Prod Res Ctr, Hat Yai 90112, Songkhla, Thailand

[4] Prince Songkla Univ, Fac Sci, Dept Microbiol, Hat Yai 90112, Songkhla, Thailand

[5] Natl Ctr Genet Engn & Biotechnol BIOTEC, Klongluang 12120, Pathumthani, Thailand

来源：

PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 04期

关键词：

Phomopsis sp; Mangrove-derived fungus; Tetrahydroanthraquinone derivatives; Antibacterial activity; Cytotoxicity; ENDOPHYTIC FUNGUS; BIOACTIVE METABOLITES; BIOSYNTHESIS; PIGMENTS;

D O I：

10.1016/j.phytol.2012.08.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

One new tetrahydroanthraquinone derivative, (2R,3S)-7-ethyl-1,2,3,4-tetrahydro-2,3,8-trihydroxy-6-methoxy- 3-methyl-9,10-anthracenedione (1), together with five known anthraquinones (2-6), two known phenylethyl alcohols (7-8) and one known butanamide (9), were isolated from the mangrove-derived fungus Phomopsis sp. PSU-MA214. Their structures were established by spectroscopic evidence. Compound 1 is a rare ethyltetrahydroanthraquinone and exhibited weak cytotoxicity against breast cancer (MCF-7) cell lines and antibacterial activity against the standard Staphylococcus aureus ATCC25923 and methicillin-resistant S. aureus SK1. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：738 / 742

页数：5

共 31 条

[1] Mansoquinone: Isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp Eg5 [J].