Asymmetric Horner-Wadsworth-Emmons reactions with meso-dialdehydes:: Scope, mechanism, and synthetic applications

被引：0

作者：

Rein, T ^{[1
]}

Vares, L

Kawasaki, I

Pedersen, TM

Norrby, PO

Brandt, P

Tanner, D

机构：

[1] Tech Univ Denmark, Dept Organ Chem, DK-2800 Lyngby, Denmark

[2] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark

[3] Royal Inst Technol, Dept Chem, S-10044 Stockholm, Sweden

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1999年 / 144卷

关键词：

asymmetric Horner-Wadsworth-Emmons reaction; chiral phosphonate; desymmetrization; meso-dialdehyde; chiral heterocycles;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric Homer-Wadsworth-Emmons reactions between chiral phosphonate reagents and various meso-dialdehydes have been investigated. A mechanistic model useful for rationalizing the experimentally observed stereoselectivities is presented. Furthermore; strategies for applying these reactions to the stereocontrolled preparation of chiral heterocyclic building blocks have been developed.

引用

页码：169 / 172

页数：4

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