Deja Vu: EGF Receptors Drive Resistance to BRAF Inhibitors

被引：22

作者：

Girotti, Maria Romina ^{[1
]}

Marais, Richard ^{[1
]}

机构：

[1] Univ Manchester, Paterson Inst Canc Res, Mol Oncol Grp, Manchester, Lancs, England

来源：

CANCER DISCOVERY | 2013年 / 3卷 / 05期

关键词：

MELANOMA; RAF;

D O I：

10.1158/2159-8290.CD-13-0131

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The promise of personalized medicine is upon us, and in some cancers, targeted therapies are rapidly becoming the mainstay of treatment for selected patients based on their molecular profile. The protein kinase BRAF is a driver oncogene in both thyroid cancer and melanoma, but while drugs that target BRAF and its downstream signaling pathway are effective in melanoma, they are ineffective in thyroid cancer. In this issue of Cancer Discovery, Montero-Conde and colleagues investigate why thyroid cancer is resistant to BRAF inhibitors despite the presence of BRAF mutation. Cancer Discov; 3(5); 487-90. (C) 2013 AACR.

引用

页码：487 / 490

页数：4

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