Chromothripsis, a credible chromosomal mechanism in evolutionary process

被引:10
作者
Pellestor, Franck [1 ,2 ]
Gatinois, Vincent [1 ,2 ]
机构
[1] Montpellier CHRU, Arnaud de Villeneuve Hosp, Dept Med Genet, Unit Chromosomal Genet, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier 5, France
[2] St Eloi Hosp, Inst Regenerat Med & Biotherapies, INSERM Genome & Stem Cell Plast Dev & Aging 1183, Montpellier, France
关键词
Chromothripsis; Chromosomal rearrangements; Macroevolution; Speciation; Adaptation; TRANSPOSABLE ELEMENTS; STRUCTURAL VARIATION; GENOME; REARRANGEMENTS; CANCER; RETROTRANSPOSITION; BREAKPOINTS; BREAKS; GENES; ARISE;
D O I
10.1007/s00412-018-0679-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recent discovery of a new class of massive chromosomal rearrangements, occurring during one unique cellular event and baptized chromothripsis, deeply modifies our perception on the genesis of complex genomic rearrangements, but also, it raises the question of the potential driving role of chromothripsis in species evolution. Analyses of the etiology of chromothripsis have led to the identification of various cellular processes capable of generating chromothripsis, such as premature chromosome condensation, telomere dysfunction, abortive apoptosis, and micronucleus formation. All these causative mechanisms may occur in germlines or during early embryonic development, suggesting that chromothripsis could be an unexpected mechanism for profound genome modification. The occurrence of chromothripsis appears to be in good agreement with macroevolution models proposed as a complement to phyletic gradualism. Various cases of chromosomal speciation and short-term adaptation could be correlated to chromothripsis-mediated mechanism. The emergency of this unanticipated chaotic phenomenon may contribute to demonstrate the contribution of chromosome rearrangements to speciation process. New sequencing and bioinformatics methods can be expected to shed new light on the role of chromothripsis in evolutionary process.
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页码:1 / 6
页数:6
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