Production of 8-OHdG and cytochrome c by cultured human mononuclear cells in patients with autoimmune thyroid disease

被引：11
作者：
Hara, H [1 ]
Sato, R [1 ]
Ban, Y [1 ]
机构：
[1] Showa Univ, Sch Med, Dept Internal Med 3, Shinagawa Ku, Tokyo 1428666, Japan
来源：
ENDOCRINE JOURNAL | 2001年 / 48卷 / 06期
关键词：
8-OHdG; cytochrome c; autoimmune thyroid disease;
D O I：
10.1507/endocrj.48.671
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Since oxidative stress is related to autoimmune thyroid disease, we studied the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cytochrome c by culture of mononuclear cells from patients with Graves' disease and Hashimoto's thyroiditis. In patients with untreated Graves' dis,mse, 8-OHdG and cytochrome c levels in culture supernatant of mononuclear cells were significantly higher than those of healthy control subjects, while the cytochrome c levels were significantly higher in patients with untreated Craves' disease and Hashimoto's thyroiditis than those of control subjects. Significant correlations between 8-OHdG and FT4, and cytochrome c were found. These results indicated that thyroid function has a potent influence on ox dative stress.
引用
收藏
页码：671 / 675
页数：5
相关论文
共 19 条
  • [1] Communication -: Superoxide in apoptosis -: Mitochondrial generation triggered by cytochrome c loss
    Cai, JY
    Jones, DP
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (19) : 11401 - 11404
  • [2] CULTUR RG, 1991, AM J CLIN NUTR, V53, pS373
  • [3] THE HUMAN SOMATIC CYTOCHROME-C GENE - 2 CLASSES OF PROCESSED PSEUDOGENES DEMARCATE A PERIOD OF RAPID MOLECULAR EVOLUTION
    EVANS, MJ
    SCARPULLA, RC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) : 9625 - 9629
  • [4] OXIDATIVE DAMAGE TO DNA DURING AGING - 8-HYDROXY-2'-DEOXYGUANOSINE IN RAT ORGAN DNA AND URINE
    FRAGA, CG
    SHIGENAGA, MK
    PARK, JW
    DEGAN, P
    AMES, BN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4533 - 4537
  • [5] Differential regulation of Fas-mediated apoptosis in both thyrocyte and lymphocyte cellular compartments correlates with opposite phenotypic manifestations of autoimmune thyroid disease
    Giordano, C
    Richiusa, P
    Bagnasco, M
    Pizzolanti, G
    Di Blasi, F
    Sbriglia, MS
    Mattina, A
    Pesce, G
    Montagna, P
    Capone, F
    Misiano, G
    Scorsone, A
    Pugliese, A
    Galluzzo, A
    [J]. THYROID, 2001, 11 (03) : 233 - 244
  • [6] Differential requirement for Caspase 9 in apoptotic pathways in vivo
    Hakem, R
    Hakem, A
    Duncan, GS
    Henderson, JT
    Woo, M
    Soengas, MS
    Elia, A
    de la Pompa, JL
    Kagi, D
    Khoo, W
    Potter, J
    Yoshida, R
    Kaufman, SA
    Lowe, SW
    Penninger, JM
    Mak, TW
    [J]. CELL, 1998, 94 (03) : 339 - 352
  • [7] Hara Hideo, 1993, Folia Endocrinologica Japonica, V69, P87
  • [8] Reactive oxygen species regulate activation-induced T cell apoptosis
    Hildeman, DA
    Mitchell, T
    Teague, TK
    Henson, P
    Day, BJ
    Kappler, J
    Marrack, PC
    [J]. IMMUNITY, 1999, 10 (06) : 735 - 744
  • [9] Knight JA, 2000, ANN CLIN LAB SCI, V30, P145
  • [10] Effects of thyroid hormones on apoptotic cell death of human lymphocytes
    Mihara, S
    Suzuki, N
    Wakisaka, S
    Suzuki, S
    Sekita, N
    Yamamoto, S
    Saito, N
    Hoshino, T
    Sakane, T
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (04) : 1378 - 1385
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