Production of 8-OHdG and cytochrome c by cultured human mononuclear cells in patients with autoimmune thyroid disease

被引：11

作者：

Hara, H ^{[1
]}

Sato, R ^{[1
]}

Ban, Y ^{[1
]}

机构：

[1] Showa Univ, Sch Med, Dept Internal Med 3, Shinagawa Ku, Tokyo 1428666, Japan

来源：

ENDOCRINE JOURNAL | 2001年 / 48卷 / 06期

关键词：

8-OHdG; cytochrome c; autoimmune thyroid disease;

D O I：

10.1507/endocrj.48.671

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since oxidative stress is related to autoimmune thyroid disease, we studied the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cytochrome c by culture of mononuclear cells from patients with Graves' disease and Hashimoto's thyroiditis. In patients with untreated Graves' dis,mse, 8-OHdG and cytochrome c levels in culture supernatant of mononuclear cells were significantly higher than those of healthy control subjects, while the cytochrome c levels were significantly higher in patients with untreated Craves' disease and Hashimoto's thyroiditis than those of control subjects. Significant correlations between 8-OHdG and FT4, and cytochrome c were found. These results indicated that thyroid function has a potent influence on ox dative stress.

引用

页码：671 / 675

页数：5

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