Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa

被引：33

作者：

Szamosvari, David ^{[1
]}

Reichle, Valentin F. ^{[1
]}

Jureschi, Monica ^{[1
]}

Boettcher, Thomas ^{[1
]}

机构：

[1] Univ Konstanz, Dept Chem, Konstanz Res Sch Chem Biol, D-78457 Constance, Germany

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 92期

关键词：

QUORUM-SENSING SYSTEMS; TO-CELL COMMUNICATION; FACTOR LASB; PQS; CYCLIZATION; INFECTIONS; MODULATORS; DISCOVERY; CHELATOR; INSIGHTS;

D O I：

10.1039/c6cc06295d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.

引用

页码：13440 / 13443

页数：4

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