Enhanced cocaine self-administration in adult rats prenatally exposed to cocaine

被引:54
作者
Keller, RW
LeFevre, R
Raucci, J
Carlson, JN
Glick, SD
机构
[1] Dept. Pharmacol. Neurosci., A-136, Albany Medical College, Albany, NY 12208
关键词
prenatal; cocaine; self-administration; reward; cocaine self-administration; rats; reinforcement;
D O I
10.1016/0304-3940(96)12409-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rats that had been prenatally exposed to either cocaine or saline were examined as adults using continuous reinforcement (FR1) cocaine self-administration. Initially these rats were water-deprived and trained to bar-press for water; no differences across prenatal treatments were observed during this training phase. After complete rehydration and implantation of an intravenous cannula into the external jugular vein, animals were introduced to cocaine self-administration with a nocturnal and subsequent 3 h exposure. During daily test sessions rats were allowed to self-administer cocaine for 1 h/day. Prenatal cocaine exposure led to a marked and stable enhancement of the rates of self-administration for up to 13 days, the longest time point examined. These results suggest that prenatal cocaine exposure can alter cocaine reinforcement in adult animals.
引用
收藏
页码:153 / 156
页数:4
相关论文
共 29 条
[1]   PRENATAL COCAINE EXPOSURE DISRUPTS THE DEVELOPMENT OF THE SEROTONERGIC SYSTEM [J].
AKBARI, HM ;
KRAMER, HK ;
WHITAKERAZMITIA, PM ;
SPEAR, LP ;
AZMITIA, EC .
BRAIN RESEARCH, 1992, 572 (1-2) :57-63
[2]  
AZUMA SD, 1993, PEDIATRICS, V92, P396
[3]  
Chasnoff I J, 1992, Curr Probl Pediatr, V22, P302, DOI 10.1016/0045-9380(92)90027-V
[4]  
CHASNOFF IJ, 1992, PEDIATRICS, V89, P284
[5]   SAYING GOODBYE TO THE CRACK BABY [J].
COLES, CD .
NEUROTOXICOLOGY AND TERATOLOGY, 1993, 15 (05) :290-292
[6]  
GALLOWAY MP, 1992, COCAINE PHARM PHYSL, P163
[7]   NEUROCHEMICAL PREDISPOSITION TO SELF-ADMINISTER COCAINE IN RATS - INDIVIDUAL-DIFFERENCES IN DOPAMINE AND ITS METABOLITES [J].
GLICK, SD ;
RAUCCI, J ;
WANG, S ;
KELLER, RW ;
CARLSON, JN .
BRAIN RESEARCH, 1994, 653 (1-2) :148-154
[8]   DIFFERENCES IN AMPHETAMINE AND MORPHINE SENSITIVITY IN LATERALIZED AND NON-LATERALIZED RATS - LOCOMOTOR-ACTIVITY AND DRUG SELF-ADMINISTRATION [J].
GLICK, SD ;
HINDS, PA .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 118 (03) :239-244
[9]   FOOD-DEPRIVATION AND STIMULANT SELF-ADMINISTRATION IN RATS - DIFFERENCES BETWEEN COCAINE AND D-AMPHETAMINE [J].
GLICK, SD ;
HINDS, PA ;
CARLSON, JN .
PSYCHOPHARMACOLOGY, 1987, 91 (03) :372-374
[10]   CORTICAL DOPAMINERGIC INVOLVEMENT IN COCAINE REINFORCEMENT [J].
GOEDERS, NE ;
SMITH, JE .
SCIENCE, 1983, 221 (4612) :773-775