Can Nitric Oxide-Based Therapy Prevent Bronchopulmonary Dysplasia?

被引：9

作者：

Raffay, Thomas M. ^{[1
]}

Martin, Richard J. ^{[1
]}

Reynolds, James D. ^{[2
,3
]}

机构：

[1] Univ Hosp Cleveland, Rainbow Babies & Childrens Hosp, Dept Pediat, Div Neonatol,Case Med Ctr, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Inst Transformat Mol Med, Cleveland, OH 44106 USA

[3] Univ Hosp Cleveland, Dept Anesthesia & Perioperat Med, Case Med Ctr, Cleveland, OH 44106 USA

来源：

CLINICS IN PERINATOLOGY | 2012年 / 39卷 / 03期

关键词：

Inhaled nitric oxide (iNO); Bronchopulmonary dysplasia (BPD); Neonate; Prematurity; S-nitrosylation; S-nitrosothiol (SNO); Ethyl nitrite (ENO); PERSISTENT PULMONARY-HYPERTENSION; RANDOMIZED CONTROLLED-TRIAL; CHRONIC LUNG-DISEASE; SEVERE RESPIRATORY-FAILURE; ENDOTHELIAL GROWTH-FACTOR; RED-BLOOD-CELLS; NF-KAPPA-B; RISK PRETERM INFANTS; SMOOTH-MUSCLE-CELLS; S-NITROSYLATION;

D O I：

10.1016/j.clp.2012.06.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A growing understanding of endogenous nitric oxide (NO) biology is helping to explain how and when exogenous NO may confer benefit or harm; this knowledge is also helping to identify new better-targeted NO-based therapies. In this review, results of the bronchopulmonary dysplasia clinical trials that used inhaled NO in the preterm population are placed in context, the biologic basis for novel NO therapeutics is considered, and possible future directions for NO-focused clinical and basic research in developmental lung disease are identified.

引用

页码：613 / +

页数：27

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