Outbreaks of human monkeypox after cessation of smallpox vaccination

被引：160

作者：

Reynolds, Mary G. ^{[1
]}

Damon, Inger K. ^{[1
]}

机构：

[1] US Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA

来源：

TRENDS IN MICROBIOLOGY | 2012年 / 20卷 / 02期

关键词：

monkeypox; smallpox vaccine; emerging infectious disease; immune evasion; ecological niche; Congo Basin; PROTECTS NONHUMAN-PRIMATES; MODIFIED VACCINIA VIRUS; DNA VACCINE; LETHAL MONKEYPOX; CONGO BASIN; AFRICAN STRAINS; NORTH-AMERICAN; UNITED-STATES; WEST-AFRICAN; RISK-FACTORS;

D O I：

10.1016/j.tim.2011.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC) prompts the question of whether cessation of smallpox vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the historic geographic range of the virus? Research addressing the virus's mechanisms for immune evasion and induction, as well as that directed at elucidating the genes involved in pathogenesis in different viral lineages (West African vs Congo Basin), provide insights to help explain why emergence appears to be geographically limited. Novel vaccines offer one solution to curtail the spread of this disease.

引用

页码：80 / 87

页数：8

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