HLA variation and disease

被引：512

作者：

Dendrou, Calliope A. ^{[1
]}

Petersen, Jan ^{[2
,3
,4
]}

Rossjohn, Jamie ^{[2
,3
,4
,5
]}

Fugger, Lars ^{[6
,7
,8
]}

机构：

[1] Univ Oxford, Wellcome Ctr Human Genet, Nuffield Dept Med, Roosevelt Dr, Oxford OX3 7BN, England

[2] Monash Univ, Australian Res Council, Ctr Excellence Adv Mol Imaging, Wellington Rd, Clayton, Vic 3800, Australia

[3] Monash Univ, Biomed Discovery Inst, Infect & Immun Programme, Wellington Rd, Clayton, Vic 3800, Australia

[4] Monash Univ, Biomed Discovery Inst, Dept Biochem & Mol Biol, Wellington Rd, Clayton, Vic 3800, Australia

[5] Cardiff Univ, Sch Med, Div Infect & Immun, Heath Pk, Cardiff CF14 4XN, S Glam, Wales

[6] Univ Copenhagen, Rigshosp, Danish Natl Res Fdn, Ctr PERSIMUNE, DK-2100 Copenhagen, Denmark

[7] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med,Div Clin Neurol, Oxford Ctr Neuroinflammat,Nuffield Dept Clin Neus, Headley Way, Oxford OX3 9DS, England

[8] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Med Res Council,Human Immunol Unit, Headley Way, Oxford OX3 9DS, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2018年 / 18卷 / 05期

基金：

新加坡国家研究基金会; 英国惠康基金; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

MHC CLASS-I; CELL-RECEPTOR RECOGNITION; T-CELLS; CELIAC-DISEASE; ANTIGEN PRESENTATION; TISSUE TRANSGLUTAMINASE; MULTIPLE-SCLEROSIS; EXPRESSION LEVELS; CROSS-REACTIVITY; GLIADIN PEPTIDES;

D O I：

10.1038/nri.2017.143

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA-ligand interactions for clinical benefit is becoming a realistic prospect.

引用

页码：325 / 339

页数：15

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