Association Between Vitamin D Deficiency and Suspected Nonalcoholic Fatty Liver Disease in an Adolescent Population

被引:18
作者
Cho, Young Hoon [1 ]
Kim, Ju Whi [1 ]
Shim, Jung Ok [2 ]
Yang, Hye Ran [1 ]
Chang, Ju Young [1 ]
Moon, Jin Soo [1 ]
Ko, Jae Sung [1 ]
机构
[1] Seoul Natl Univ, Dept Pediat, Coll Med, 103 Daehak Ro, Seoul 03080, South Korea
[2] Korea Univ, Dept Pediat, Med Ctr, Seoul, South Korea
关键词
Vitamin D deficiency; Nonalcoholic fatty liver disease; Alanine transaminase; Adolescent; Children; Obesity; METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; CHILDREN; OBESITY; PREVALENCE; RISK;
D O I
10.5223/pghn.2019.22.3.233
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Purpose: Vitamin D deficiency is a condition widespread throughout the world. Recent studies have suggested that vitamin D deficiency was associated with obesity and metabolic syndrome. The purpose of the study was to examine the relationship between vitamin D deficiency and nonalcoholic fatty liver disease (NAFLD) in adolescents. Methods: The data were obtained from the Korean National Health and Nutrition Examination Survey from 2008-2014. A total of 3,878 adolescents were included in the study. Vitamin D deficiency was defined as a 25-hydroxyvitamin D concentration < 20 ng/mL and suspected NAFLD was defined as an alanine transaminase concentration > 30 U/L. Results: Vitamin D deficiency was noted in 78.9% of the studied population. Age, body mass index, waist circumference, and blood pressure, glucose, cholesterol, and triglyceride levels were significantly higher in adolescents with suspected NAFLD than in adolescents without suspected NAFLD, while the mean vitamin D level was significantly lower in adolescents with suspected NAFLD. The multivariate-adjusted odds of suspected NAFLD were higher with increased age, male gender, obesity, and metabolic syndrome. Individuals with vitamin D deficiency were at higher risk of suspected NAFLD (odds ratio, 1.77; 95% confidence interval, 1.07-2.95) after adjusting for age, gender, obesity, and metabolic syndrome. Conclusion: Vitamin D deficiency was associated with suspected NAFLD, independent of obesity and metabolic syndrome, in adolescents.
引用
收藏
页码:233 / 241
页数:9
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