HPV Vaccine: Updates and Highlights

被引：66

作者：

de Oliveira, Cristina Mendes ^{[1
]}

Fregnani, Jose Humberto T. G. ^{[1
,2
]}

Villa, Luisa Lina ^{[3
]}

机构：

[1] Barretos Canc Hosp, HPV Res Grp, Barretos, SP, Brazil

[2] AC Camargo Canc Ctr, Sao Paulo, SP, Brazil

[3] Univ Sao Paulo, Inst Canc Estado Sao Paulo, Fac Med, Sao Paulo, SP, Brazil

来源：

ACTA CYTOLOGICA | 2019年 / 63卷 / 02期

关键词：

Papillomavirus infections; HPV vaccines; Clinical efficacy; Clinical trials; State of the art reviews; HUMAN-PAPILLOMAVIRUS VACCINATION; YOUNG-WOMEN; INTRAEPITHELIAL NEOPLASIA; QUADRIVALENT VACCINE; CERVICAL-CANCER; GENITAL WARTS; IMMUNOGENICITY; PREVALENCE; EFFICACY; VIRUS;

D O I：

10.1159/000497617

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

HPV is the most common sexually transmitted biological agent and is the cause of many conditions in men and women, including precancer lesions and cancer. Three prophylactic HPV vaccines targeting high-risk HPV types are available in many countries worldwide: 2-, 4- and 9-valent vaccines. All the 3 vaccines use recombinant DNA technology and are prepared from the purified L1 protein that self-assembles to form HPV type-specific empty shells. This non-systematic review aims to summarize the HPV epidemiology and the vaccine development to review the landmark trials of HPV vaccine, to present to most remarkable results from clinical trials and the real world, and to stress the challenges and the barriers for HPV vaccine implementation. (C) 2019 S. Karger AG, Basel

引用

页码：159 / 168

页数：10

共 78 条

[1] E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1 [J].

Accardi, Rosita ;

Rubino, Rosa ;

Scalise, Mariafrancesca ;

Gheit, Tarik ;

Shahzad, Naveed ;

Thomas, Miranda ;

Banks, Lawrence ;

Indiveri, Cesare ;

Sylla, Bakary S. ;

Cardone, Rosa A. ;

Reshkin, Stephan J. ;

Tommasino, Massimo .

JOURNAL OF VIROLOGY, 2011, 85 (16) :8208-8216

[2] Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide [J].

Alemany, Laia ;

Saunier, Maelle ;

Alvarado-Cabrero, Isabel ;

Quiros, Beatriz ;

Salmeron, Jorge ;

Shin, Hai-Rim ;

Pirog, Edyta C. ;

Guimera, Nuria ;

Hernandez-Suarez, Gustavo ;

Felix, Ana ;

Clavero, Omar ;

Lloveras, Belen ;

Kasamatsu, Elena ;

Goodman, Marc T. ;

Hernandez, Brenda Y. ;

Laco, Jan ;

Tinoco, Leopoldo ;

Geraets, Daan T. ;

Lynch, Charles F. ;

Mandys, Vaclav ;

Poljak, Mario ;

Jach, Robert ;

Verge, Josep ;

Clavel, Christine ;

Ndiaye, Cathy ;

Klaustermeier, JoEllen ;

Cubilla, Antonio ;

Castellsague, Xavier ;

Bravo, Ignacio G. ;

Pawlita, Michael ;

Quint, William G. ;

Munoz, Nubia ;

Bosch, Francesc X. ;

de Sanjose, Silvia .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (01) :98-107

[3]

[Anonymous], AM J PUBLIC HLTH

[4]

[Anonymous], VACCINE

[5]

[Anonymous], 2017, Human Papillomavirus Vaccines: WHO Position Paper

[6]

[Anonymous], VACCINE

[7]

[Anonymous], INT J GYNECOL CANC

[8]

[Anonymous], PEDIAT INFECT DIS J

[9]

[Anonymous], BEST PRACT RES CLIN

[10]

[Anonymous], REV MED SAO PAULO

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