Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography

被引：59

作者：

Herman, JL ^{[1
]}

机构：

[1] Cephalon Inc, W Chester, PA 19380 USA

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2002年 / 16卷 / 05期

关键词：

D O I：

10.1002/rcm.593

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high-throughput Absorption, Distribution, Metabolism and Excretion (ADME) screening. However, to truly take full advantage of high-throughput ADME screening, a generic method is needed that eliminates the need to develop a new method for each new compound being screened. New developments in the stationary phase of turbulent flow columns has allowed us to develop an on-line biological sample cleanup method that is suitable for over 99% of the compounds in the Cephalon database. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：421 / 426

页数：6

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