Design and implementation of a simple multinuclear MRI system for ultra high-field imaging of animals

Non-proton MRI has recently garnered gathering interest with the increased availability of ultra high field MRI system. Assuming the availability of a broadband RF amplifier, performing multinuclear MR experiments essentially requires additional hardware, such as an RF resonator and a TAR switch for each nucleus. A double- or triple-resonant RF probe is typically constructed using traps or PIN-diode circuits, but this approach degrades the signal-to-noise ratio (SNR) and image quality compared to a single resonant coil and this is a limiting factor. In this work, we have designed the required hardware for multinuclear MR imaging experiments employing six single-resonant coil sets and a purpose-built animal bed; these have been implemented into a home-integrated 9.4 T preclinical MRI scanner. System capabilities are demonstrated by distinguishing concentration differences and sensitivity of X-nuclei imaging and spectroscopy without SNR penalty for any nuclei, no subject interruption and no degradation of the static shim conditions. (C) 2016 Elsevier Inc. All rights reserved.