A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

被引：765

作者：

Okazaki, Taku ^{[1
]}

Chikuma, Shunsuke ^{[2
]}

Iwai, Yoshiko ^{[3
]}

Fagarasan, Sidonia ^{[4
]}

Honjo, Tasuku ^{[2
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Div Immune Regulat, Tokushima 770, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Immunol & Genom Med, Kyoto, Japan

[3] Univ Occupat & Environm Hlth, Sch Med, Dept Mol Biol, Kitakyushu, Fukuoka 807, Japan

[4] RIKEN Yokohama Inst, Ctr Integrat Med Sci IMS RCAI, Lab Mucosal Immun, Yokohama, Kanagawa, Japan

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 12期

基金：

日本科学技术振兴机构;

关键词：

T-CELLS; REGULATORY T; DILATED CARDIOMYOPATHY; PROGRAMMED DEATH-1; TUMOR-IMMUNOTHERAPY; NEGATIVE REGULATOR; CRYSTAL-STRUCTURE; EFFECTOR PHASE; CUTTING EDGE; TGF-BETA;

D O I：

10.1038/ni.2762

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment.

引用

页码：1212 / 1218

页数：7

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