Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

被引：382

作者：

Kanzaki, M ^{[1
]}

Zhang, YQ ^{[1
]}

Mashima, H ^{[1
]}

Li, L ^{[1
]}

Shibata, H ^{[1
]}

Kojima, I ^{[1
]}

机构：

[1] Gunma Univ, Inst Mol & Cell Regulat, Dept Cell Biol, Maebashi, Gumma 3718512, Japan

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 03期

关键词：

D O I：

10.1038/11086

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium plays a critical part in the regulation of cell growth, and growth factors stimulate calcium entry into cells through calcium-permeable channels. However, the molecular nature and regulation of calcium-permeable channels are still unclear at present. Here we report the molecular characterization of a calcium-permeable cation channel that is regulated by insulin-like growth factor-I (IGF-I). This channel, which we name growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular poets under basal conditions. Upon stimulation of cells by IGF-I, GRC translocates to the plasma membrane. Thus, IGF-I augments calcium entry through GRC by regulating trafficking of the channel.

引用

页码：165 / 170

页数：6

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