Aryne Insertion Reactions Leading to Bioactive Fused Quinazolinones: Diastereoselective Total Synthesis of Cruciferane

被引：79

作者：

Vaidya, Sagar D. ^{[1
]}

Argade, Narshinha P. ^{[1
]}

机构：

[1] CSIR, Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 15期

关键词：

HETEROCYCLES; ALKALOIDS; EFFICIENT; TRYPTANTHRIN; DERIVATIVES; CHEMISTRY; ARYLATION; BENZYNE; BONDS;

D O I：

10.1021/ol4018062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Insertion reactions of an in situ generated arynes to a variety of suitably substituted 1,3-quinazolin-4-ones have been demonstrated for a new efficient one-step approach to a diverse range of fused quinazolinone architectures. The present protocol has been effectively utilized to accomplish the concise total synthesis of recently isolated bioactive natural products tryptanthrin, phaitanthrins A-C, and cruciferane.

引用

页码：4006 / 4009

页数：4

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