CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival

被引：6

作者：

Asai, Nobuhiro ^{[1
]}

Kubo, Akihito ^{[1
]}

Suzuki, Susumu ^{[2
]}

Murotani, Kenta ^{[3
]}

Numanami, Hiroki ^{[4
]}

Yoshikawa, Kazuhiro ^{[5
]}

Ueda, Ryuzo ^{[2
]}

Yamaguchi, Etsuro ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Internal Med, Div Resp Med & Allergol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[2] Aichi Med Univ, Dept Tumor Immunol, Sch Med, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[3] Aichi Med Univ, Clin Res Ctr, Sch Med, Div Biostat, Nagakute, Aichi, Japan

[4] Aichi Med Univ, Div Chest Surg, Sch Med, Dept Surg, Nagakute, Aichi, Japan

[5] Aichi Med Univ, Promoting Ctr Clin Res, Sch Med, Nagakute, Aichi, Japan

来源：

CANCER INVESTIGATION | 2019年 / 37卷 / 03期

关键词：

Non-small cell lung cancer; Squamous cell carcinoma of the lung; Regulatory T cell; CCR4; Foxp3; HUMANIZED ANTI-CCR4 ANTIBODY; LEUKEMIA-LYMPHOMA; SUPPRESSOR-CELLS; FOXP3; EXPRESSION; CANCER; PROGRESSION; KW-0761; LYMPHOCYTES;

D O I：

10.1080/07357907.2019.1582848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4(+) eTregs to total Tregs (40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p=.007) and overall survival (OR: 3.76, p=.037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.

引用

页码：163 / 173

页数：11

共 50 条

[41] Tumor-Infiltrating Foxp3+Regulatory T Cells are Correlated with Cyclooxygenase-2 Expression and are Associated with Recurrence in Resected Non-small Cell Lung Cancer [J].

Shimizu, Katsuhiko ;

Nakata, Masao ;

Hirami, Yuji ;

Yukawa, Takuro ;

Maeda, Ai ;

Tanemoto, Kazuo .

JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (05) :585-590

[42] Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma [J].

Kang, Myoung Jae ;

Kim, Kyoung Min ;

Bae, Jun Sang ;

Park, Ho Sung ;

Lee, Ho ;

Chung, Myoung Ja ;

Moon, Woo Sung ;

Lee, Dong Geun ;

Jang, Kyu Yun .

TRANSLATIONAL ONCOLOGY, 2013, 6 (03) :282-289

[43] Developing and validating the model of tumor-infiltrating immune cell to predict survival in patients receiving radiation therapy for head and neck squamous cell carcinoma [J].

Xu, Ting ;

Xu, Mengting ;

Xu, Yiying ;

Cai, Xiaojun ;

Brenner, Michael J. ;

Twigg, Joshua ;

Fei, Zhaodong ;

Chen, Chuanben .

TRANSLATIONAL CANCER RESEARCH, 2024, 13 (01) :394-412

[44] Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer [J].

Salama, Paul ;

Phillips, Michael ;

Grieu, Fabienne ;

Morris, Melinda ;

Zeps, Nik ;

Joseph, David ;

Platell, Cameron ;

Iacopetta, Barry .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (02) :186-+

[45] Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma [J].

Piersiala, Krzysztof ;

Hjalmarsson, Eric ;

Lagebro, Vilma ;

da Silva, Pedro Farrajota Neves ;

Bark, Rusana ;

Elliot, Alexandra ;

Marklund, Linda ;

Margolin, Gregori ;

Georen, Susanna Kumlien ;

Cardell, Lars-Olaf .

FRONTIERS IN IMMUNOLOGY, 2024, 15

[46] Construction of a predictive model for immunotherapy efficacy in lung squamous cell carcinoma based on the degree of tumor-infiltrating immune cells and molecular typing [J].

Yang, Lingge ;

Wei, Shuli ;

Zhang, Jingnan ;

Hu, Qiongjie ;

Hu, Wansong ;

Cao, Mengqing ;

Zhang, Long ;

Wang, Yongfang ;

Wang, Pingli ;

Wang, Kai .

JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 20 (01)

[47] Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells [J].

Ding, Rui ;

Yu, Xiaoyan ;

Hu, Zhilin ;

Dong, Yu ;

Huang, Haiyan ;

Zhang, Yuerong ;

Han, Qiaoqiao ;

Ni, Zhi-Yu ;

Zhao, Ren ;

Ye, Youqiong ;

Zou, Qiang .

IMMUNITY, 2024, 57 (03) :528-540.e6

[48] Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck [J].

Boucek, Jan ;

Mrkvan, Tomas ;

Chovanec, Martin ;

Kuchar, Martin ;

Betka, Jaroslav ;

Boucek, Vladimir ;

Hladikova, Marie ;

Betka, Jan ;

Eckschlager, Tomas ;

Rihova, Blanka .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (1-2) :426-433

[49] Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers [J].

Kim, Moon-Young ;

Koh, Jaemoon ;

Kim, Sehui ;

Go, Heounjeong ;

Jeon, Yoon Kyung ;

Chung, Doo Hyun .

LUNG CANCER, 2015, 88 (01) :24-33

[50] Antagonization of CCR4 leads to failure of activated regulatory T-cell migration in a mice model of head and neck squamous cell carcinoma [J].

Li, Wei-Jin ;

Sun, Wei ;

We, Fan-Qin ;

Wen, Wei-Ping .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (09) :9333-9342

← 1 2 3 4 5 →