CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival

被引：6

作者：

Asai, Nobuhiro ^{[1
]}

Kubo, Akihito ^{[1
]}

Suzuki, Susumu ^{[2
]}

Murotani, Kenta ^{[3
]}

Numanami, Hiroki ^{[4
]}

Yoshikawa, Kazuhiro ^{[5
]}

Ueda, Ryuzo ^{[2
]}

Yamaguchi, Etsuro ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Internal Med, Div Resp Med & Allergol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[2] Aichi Med Univ, Dept Tumor Immunol, Sch Med, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[3] Aichi Med Univ, Clin Res Ctr, Sch Med, Div Biostat, Nagakute, Aichi, Japan

[4] Aichi Med Univ, Div Chest Surg, Sch Med, Dept Surg, Nagakute, Aichi, Japan

[5] Aichi Med Univ, Promoting Ctr Clin Res, Sch Med, Nagakute, Aichi, Japan

来源：

CANCER INVESTIGATION | 2019年 / 37卷 / 03期

关键词：

Non-small cell lung cancer; Squamous cell carcinoma of the lung; Regulatory T cell; CCR4; Foxp3; HUMANIZED ANTI-CCR4 ANTIBODY; LEUKEMIA-LYMPHOMA; SUPPRESSOR-CELLS; FOXP3; EXPRESSION; CANCER; PROGRESSION; KW-0761; LYMPHOCYTES;

D O I：

10.1080/07357907.2019.1582848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4(+) eTregs to total Tregs (40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p=.007) and overall survival (OR: 3.76, p=.037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.

引用

页码：163 / 173

页数：11

共 50 条

[31] Clonal Expansion of Tumor-Infiltrating T Cells and Analysis of the Tumor Microenvironment within Esophageal Squamous Cell Carcinoma Relapsed after Definitive Chemoradiation Therapy [J].

Mori, Takahiro ;

Kumagai, Kenichi ;

Nasu, Keisuke ;

Yoshizawa, Takamasa ;

Kuwano, Koji ;

Hamada, Yoshiki ;

Kanazawa, Hideki ;

Suzuki, Ryuji .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (03) :1-12

[32] Prognostic Impact of Immune Microenvironment in Lung Squamous Cell Carcinoma Tumor-Infiltrating CD10+ Neutrophil/CD20+ Lymphocyte Ratio as an Independent Prognostic Factor [J].

Kadota, Kyuichi ;

Nitadori, Jun-ichi ;

Ujiie, Hideki ;

Buitrago, Daniel H. ;

Woo, Kaitlin M. ;

Sima, Camelia S. ;

Travis, William D. ;

Jones, David R. ;

Adusumilli, Prasad S. .

JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) :1301-1310

[33] CCR4 is a prognostic biomarker and correlated with immune infiltrates in head and neck squamous cell carcinoma [J].

Zhang, Yijian ;

Chen, Kai ;

Li, Li ;

Mao, Weidong ;

Shen, Dong ;

Yao, Ninghua ;

Zhang, Lei .

ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (18)

[34] Tumor-infiltrating CD4+ T cells in patients with gastric cancer [J].

Yuan, Long ;

Xu, Benling ;

Yuan, Peng ;

Zhou, Jinxue ;

Qin, Peng ;

Han, Lu ;

Chen, Guangyu ;

Wang, Zhenlei ;

Run, Zengci ;

Zhao, Peng ;

Gao, Quanli .

CANCER CELL INTERNATIONAL, 2017, 17

[35] Tumor-infiltrating CD8+ T-cell density is an independent prognostic marker for oral squamous cell carcinoma [J].

Shimizu, Shota ;

Hiratsuka, Hiroyoshi ;

Koike, Kazushige ;

Tsuchihashi, Kei ;

Sonoda, Tomoko ;

Ogi, Kazuhiro ;

Miyakawa, Akira ;

Kobayashi, Junichi ;

Kaneko, Takeshi ;

Igarashi, Tontohiro ;

Hasegawa, Tadashi ;

Miyazaki, Akihiro .

CANCER MEDICINE, 2019, 8 (01) :80-93

[36] Prognostic value of tumor-infiltrating Foxp3+regulatory T cells in patients with breast cancer: a meta-analysis [J].

Zhou, Yu ;

Shao, Nan ;

Aierken, Nijiati ;

Xie, Chuanbo ;

Ye, Runyi ;

Qian, Xueke ;

Hu, Ziye ;

Zhang, Jin ;

Lin, Ying .

JOURNAL OF CANCER, 2017, 8 (19) :4098-4105

[37] Identification of a Prognostic Signature Based on Tumor-Infiltrating B Lymphocyte mRNA in Head and Neck Squamous Cell Carcinoma [J].

Zhang, Mingjun ;

Sun, Qi ;

Yao, Yisong ;

Chen, Xi ;

Li, Jiaxuan ;

Yuan, Ting ;

Mou, Yakui ;

Li, Yumei ;

Song, Xicheng .

JOURNAL OF IMMUNOLOGY RESEARCH, 2025, 2025 (01)

[38] Prognostic impact of LILRB4 expression on tumor-infiltrating cells in resected non-small cell lung cancer [J].

Kumata, Sakiko ;

Notsuda, Hirotsugu ;

Su, Mei-Tzu ;

Saito-Koyama, Ryoko ;

Tanaka, Ryota ;

Suzuki, Yuyo ;

Funahashi, Junichi ;

Endo, Shota ;

Yokota, Isao ;

Takai, Toshiyuki ;

Okada, Yoshinori .

THORACIC CANCER, 2023, 14 (21) :2057-2068

[39] Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinoma [J].

Bellmunt, J. ;

Mullane, S. A. ;

Werner, L. ;

Fay, A. P. ;

Callea, M. ;

Leow, J. J. ;

Taplin, M. E. ;

Choueiri, T. K. ;

Hodi, F. S. ;

Freeman, G. J. ;

Signoretti, S. .

ANNALS OF ONCOLOGY, 2015, 26 (04) :812-817

[40] Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of esophageal squamous cell carcinoma [J].

Nishimura, Junya ;

Tanaka, Hiroaki ;

Yamakoshi, Yoshihito ;

Hiramatsu, Soichiro ;

Tamura, Tatsuro ;

Toyokawa, Takahiro ;

Muguruma, Kazuya ;

Maeda, Kiyoshi ;

Hirakawa, Kosei ;

Ohira, Masaichi .

ESOPHAGUS, 2019, 16 (04) :333-344

← 1 2 3 4 5 →