CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival

被引：6

作者：

Asai, Nobuhiro ^{[1
]}

Kubo, Akihito ^{[1
]}

Suzuki, Susumu ^{[2
]}

Murotani, Kenta ^{[3
]}

Numanami, Hiroki ^{[4
]}

Yoshikawa, Kazuhiro ^{[5
]}

Ueda, Ryuzo ^{[2
]}

Yamaguchi, Etsuro ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Internal Med, Div Resp Med & Allergol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[2] Aichi Med Univ, Dept Tumor Immunol, Sch Med, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[3] Aichi Med Univ, Clin Res Ctr, Sch Med, Div Biostat, Nagakute, Aichi, Japan

[4] Aichi Med Univ, Div Chest Surg, Sch Med, Dept Surg, Nagakute, Aichi, Japan

[5] Aichi Med Univ, Promoting Ctr Clin Res, Sch Med, Nagakute, Aichi, Japan

来源：

CANCER INVESTIGATION | 2019年 / 37卷 / 03期

关键词：

Non-small cell lung cancer; Squamous cell carcinoma of the lung; Regulatory T cell; CCR4; Foxp3; HUMANIZED ANTI-CCR4 ANTIBODY; LEUKEMIA-LYMPHOMA; SUPPRESSOR-CELLS; FOXP3; EXPRESSION; CANCER; PROGRESSION; KW-0761; LYMPHOCYTES;

D O I：

10.1080/07357907.2019.1582848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4(+) eTregs to total Tregs (40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p=.007) and overall survival (OR: 3.76, p=.037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.

引用

页码：163 / 173

页数：11

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