CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival

被引：6
作者：
Asai, Nobuhiro [1 ]
Kubo, Akihito [1 ]
Suzuki, Susumu [2 ]
Murotani, Kenta [3 ]
Numanami, Hiroki [4 ]
Yoshikawa, Kazuhiro [5 ]
Ueda, Ryuzo [2 ]
Yamaguchi, Etsuro [1 ]
机构：
[1] Aichi Med Univ, Sch Med, Dept Internal Med, Div Resp Med & Allergol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan
[2] Aichi Med Univ, Dept Tumor Immunol, Sch Med, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan
[3] Aichi Med Univ, Clin Res Ctr, Sch Med, Div Biostat, Nagakute, Aichi, Japan
[4] Aichi Med Univ, Div Chest Surg, Sch Med, Dept Surg, Nagakute, Aichi, Japan
[5] Aichi Med Univ, Promoting Ctr Clin Res, Sch Med, Nagakute, Aichi, Japan
来源：
CANCER INVESTIGATION | 2019年 / 37卷 / 03期
关键词：
Non-small cell lung cancer; Squamous cell carcinoma of the lung; Regulatory T cell; CCR4; Foxp3; HUMANIZED ANTI-CCR4 ANTIBODY; LEUKEMIA-LYMPHOMA; SUPPRESSOR-CELLS; FOXP3; EXPRESSION; CANCER; PROGRESSION; KW-0761; LYMPHOCYTES;
D O I：
10.1080/07357907.2019.1582848
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4(+) eTregs to total Tregs (40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p=.007) and overall survival (OR: 3.76, p=.037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.
引用
收藏
页码：163 / 173
页数：11
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