CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival

被引：6

作者：

Asai, Nobuhiro ^{[1
]}

Kubo, Akihito ^{[1
]}

Suzuki, Susumu ^{[2
]}

Murotani, Kenta ^{[3
]}

Numanami, Hiroki ^{[4
]}

Yoshikawa, Kazuhiro ^{[5
]}

Ueda, Ryuzo ^{[2
]}

Yamaguchi, Etsuro ^{[1
]}

机构：

[1] Aichi Med Univ, Sch Med, Dept Internal Med, Div Resp Med & Allergol, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[2] Aichi Med Univ, Dept Tumor Immunol, Sch Med, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[3] Aichi Med Univ, Clin Res Ctr, Sch Med, Div Biostat, Nagakute, Aichi, Japan

[4] Aichi Med Univ, Div Chest Surg, Sch Med, Dept Surg, Nagakute, Aichi, Japan

[5] Aichi Med Univ, Promoting Ctr Clin Res, Sch Med, Nagakute, Aichi, Japan

来源：

CANCER INVESTIGATION | 2019年 / 37卷 / 03期

关键词：

Non-small cell lung cancer; Squamous cell carcinoma of the lung; Regulatory T cell; CCR4; Foxp3; HUMANIZED ANTI-CCR4 ANTIBODY; LEUKEMIA-LYMPHOMA; SUPPRESSOR-CELLS; FOXP3; EXPRESSION; CANCER; PROGRESSION; KW-0761; LYMPHOCYTES;

D O I：

10.1080/07357907.2019.1582848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4(+) eTregs to total Tregs (40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p=.007) and overall survival (OR: 3.76, p=.037) in lung squamous cell carcinoma (SqCC). These results highlight the prognostic importance of the balance of tumor-infiltrating Tregs in resected lung SqCC.

引用

页码：163 / 173

页数：11

共 42 条

[21] The regulation of immune tolerance by FOXP3 [J].

Lu, Ling ;

Barbi, Joseph ;

Pan, Fan .

NATURE REVIEWS IMMUNOLOGY, 2017, 17 (11) :703-717

[22] Immuno-Oncology: Emerging Targets and Combination Therapies [J].

Marshall, Henry T. ;

Djamgoz, Mustafa B. A. .

FRONTIERS IN ONCOLOGY, 2018, 8

[23] FOXP3 Expression and Overall Survival in Breast Cancer [J].

Merlo, Andrea ;

Casalini, Patrizia ;

Carcangiu, Maria Luisa ;

Malventano, Chiara ;

Triulzi, Tiziana ;

Menard, Sylvie ;

Tagliabue, Elda ;

Balsari, Andrea .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (11) :1746-1752

[24] Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research [J].

Michaud, Dominique S. ;

Houseman, E. Andres ;

Marsit, Carmen J. ;

Nelson, Heather H. ;

Wiencke, John K. ;

Kelsey, Karl T. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2015, 24 (12) :1811-1819

[25] A Breakthrough: Macrophage-Directed Cancer Immunotherapy [J].

Mills, Charles D. ;

Lenz, Laurel L. ;

Harris, Robert A. .

CANCER RESEARCH, 2016, 76 (03) :513-516

[26] Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor [J].

Miyara, Makoto ;

Yoshioka, Yumiko ;

Kitoh, Akihiko ;

Shima, Tomoko ;

Wing, Kajsa ;

Niwa, Akira ;

Parizot, Christophe ;

Taflin, Cecile ;

Heike, Toshio ;

Valeyre, Dominique ;

Mathian, Alexis ;

Nakahata, Tatsutoshi ;

Yamaguchi, Tomoyuki ;

Nomura, Takashi ;

Ono, Masahiro ;

Amoura, Zahir ;

Gorochov, Guy ;

Sakaguchi, Shimon .

IMMUNITY, 2009, 30 (06) :899-911

[27] Regulatory T cells in tumor immunity [J].

Nishikawa, Hiroyoshi ;

Sakaguchi, Shimon .

INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (04) :759-767

[28] Tumour islet Foxp3+ T-cell infiltration predicts poor outcome in nonsmall cell lung cancer [J].

O'Callaghan, Dermot S. ;

Rexhepaj, Elton ;

Gately, Kathy ;

Coate, Linda ;

Delaney, David ;

O'Donnell, Dearbhaile M. ;

Kay, Elaine ;

O'Connell, Finbarr ;

Gallagher, William M. ;

O'Byrne, Kenneth J. .

EUROPEAN RESPIRATORY JOURNAL, 2015, 46 (06) :1762-1772

[29] Cancer Statistics, 2016 [J].

Siegel, Rebecca L. ;

Miller, Kimberly D. ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (01) :7-30

[30] Current status of immunotherapy [J].

Suzuki, Susumu ;

Ishida, Takashi ;

Yoshikawa, Kazuhiro ;

Ueda, Ryuzo .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 46 (03) :191-203

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