A Pair of Chromone Epimers and an Acetophenone Glucoside from the Mangrove Endophytic Fungus Mycosphaerella sp. L3A1

被引：4

作者：

Tan, Qi ^{[1
]}

Yang, Wencong ^{[1
]}

Zhu, Ge ^{[2
]}

Chen, Tao ^{[1
]}

Wu, Jun ^{[3
,4
]}

Zhu, Yujia ^{[5
]}

Wang, Bo ^{[1
]}

Yuan, Jie ^{[2
]}

She, Zhigang ^{[1
]}

机构：

[1] Sun Yat sen Univ, Sch Chem, Guangzhou 510006, Peoples R China

[2] Sun Yat sen Univ, Zhongshan Sch Med, Dept Biochem, Guangzhou 510080, Peoples R China

[3] Guangdong Med Univ, Guangdong Key Lab Nat Med Res & Dev, Dongguan 523808, Peoples R China

[4] Guangdong Med Univ, Coll Pharm, Dongguan 523808, Peoples R China

[5] Sun Yat sen Univ, Sch Publ Hlth, Guangzhou 510080, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 12期

基金：

中国国家自然科学基金;

关键词：

secondary metabolites; mangrove endophytic fungus; Mycosphaerella; cytotoxic activity; DERIVATIVES;

D O I：

10.1002/cbdv.202200998

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new compounds, including a pair of chromone derivatives (1-2), and an acetophenone glucoside (3), together with three known compounds (4-6), were isolated from the mangrove endophytic fungus Mycosphaerella sp. L3A1. Their structures were elucidated by HR-ESI-MS analysis and extensive spectroscopic data. The absolute configurations of new compounds were determined using single-crystal X-ray diffraction analysis, electronic circular dichroism (ECD) calculations and chemical hydrolysis. In bioassays, compound 4 showed moderate cytotoxic activity against MDA-MB-435, HCT116, and SNB19 with IC50 values in the range of 18.5-26.29 mu M.

引用

页数：8

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