The natural history of multiple sclerosis with childhood onset

被引:51
作者
Renoux, Christel [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
Vukusic, Sandra [1 ,2 ,3 ,4 ,5 ]
Confavreux, Christian [1 ,2 ,3 ,4 ,5 ]
机构
[1] Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, Serv Neurol A, F-69677 Bron, France
[2] Hosp Civils Lyon, Hop Neurol Pierre Wertheimer, EDMUS Coordinating Ctr, F-69677 Bron, France
[3] INSERM, U842, F-69003 Lyon, France
[4] Univ Lyon, F-69003 Lyon, France
[5] Univ Lyon 1, F-69003 Lyon, France
[6] McGill Univ, McGill Pharmacoepidemiol Res Unit, Ctr Hlth, Montreal, PQ, Canada
[7] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada
[8] McGill Univ, Dept Med, Montreal, PQ, Canada
关键词
Multiple sclerosis; Child; Natural history; Prognosis; Disability;
D O I
10.1016/j.clineuro.2008.04.009
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Multiple sclerosis with childhood onset has been extensively studied recently, increasing the knowledge of the characteristics and long-term evolution of the disease in this age group. It is a rare condition accounting for less than 5% of all cases with multiple sclerosis. Exacerbating-remitting forms are, by far, the most common presentation at onset. The evolution to the secondary progressive phase as well as the assignment to irreversible disability landmarks take longer in patients with childhood onset compared with patients with adult onset, as shown in the KIDMUS study. However, patients with childhood onset reach these different critical phases of the disease at a Younger age than patients with adult onset, therefore contradicting the notion of a more favorable prognosis in this age group. With respect to the pathophysiology of the disease. age at onset probably influences mainly the clinical phenotype of multiple sclerosis but not the underlying biological process. suggesting a similar pathophysiology of the disease whatever age at onset. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:897 / 904
页数:8
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