Drug Addiction and the Memory Systems of the Brain

被引:314
作者
Robbins, T. W. [1 ,2 ]
Ersche, K. D. [2 ,3 ]
Everitt, B. J. [1 ,2 ]
机构
[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England
[2] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England
[3] Univ Cambridge, Dept Psychiat, Cambridge CB2 3EB, England
来源
ADDICTION REVIEWS 2008 | 2008年 / 1141卷
基金
英国医学研究理事会; 英国惠康基金;
关键词
memory; craving; habit; amygdala; nucleus accumbens; striatum; prefrontal cortex;
D O I
10.1196/annals.1441.020
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We review drug addiction from the perspective of the hypothesis that drugs of abuse interact with distinct brain memory systems. We focus on emotional and procedural forms of memory, encompassing Pavlovian and instrumental conditioning, both for action-outcome and for stimulus-response associations. Neural structures encompassed by these systems include the amygdala, hippocampus, nucleus accumbens, and dorsal striatum. Additional influences emanate from the anterior cingulate and prefrontal cortex, which are implicated in the encoding and retrieval of drug-related memories that lead to drug craving and drug use. Finally, we consider the ancillary point that chronic abuse of many drugs may impact directly on neural memory systems via neuroadaptive and neurotoxic effects that lead to cognitive impairments in which memory dysfunction is prominent.
引用
收藏
页码:1 / 21
页数:21
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