Yolk Sac Tumor Arising in Uterine Carcinosarcoma With Endometrioid and Serous Components: A Case Report With Immunohistochemical Analysis

被引：3
作者：
Grindstaff, Samuel [1 ]
Hanley, Linda C. [2 ,3 ]
Banet, Natalie [2 ,3 ]
机构：
[1] Uniformed Serv Univ Hlth Sci, Dept Pathol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA
[2] Brown Univ, Women & Infants Hosp, Dept Pathol & Lab Med, 101 Dudley St, Providence, RI 02905 USA
[3] Brown Univ, Warren Alpert Med Sch, 101 Dudley St, Providence, RI 02905 USA
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 2022年 / 41卷 / 01期
关键词：
Yolk sac tumor; Carcinosarcoma; HER-2; Uterine serous carcinoma; AMPLIFICATION; EXPERIENCE;
D O I：
10.1097/PGP.0000000000000774
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Yolk sac tumor of the endometrium is an uncommon neoplasm. Here we report a case of yolk sac tumor arising in a uterine carcinosarcoma, with the carcinomatous component showing both endometrioid and serous components, and the sarcomatous component showing homologous (spindled) differentiation. The yolk sac tumor showed predominant glandular configuration and was present admixed with the epithelial components. Extensive immunostaining was performed to narrow the differential diagnosis, including potentially therapeutic testing for HER-2. To our knowledge, this is the first case of carcinosarcoma with this mix of epithelial components and corresponding reporting of these immune and therapeutic markers.
引用
收藏
页码：40 / 44
页数：5
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