The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients undergoing resection for colorectal cancer

被引：42

作者：

Hayama, Tamuro ^{[1
]}

Ozawa, Tsuyoshi ^{[1
]}

Okada, Yuka ^{[1
]}

Tsukamoto, Mitsuo ^{[1
]}

Fukushima, Yoshihisa ^{[1
]}

Shimada, Ryu ^{[1
]}

Nozawa, Keijiro ^{[1
]}

Matsuda, Keiji ^{[1
]}

Fujii, Shoichi ^{[2
]}

Hashiguchi, Yojiro ^{[1
]}

机构：

[1] Teikyo Univ, Dept Surg, Sch Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan

[2] Koga Hosp, Dept Surg, Yaizu, Japan

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

INFLAMMATION; SURVIVAL; SURGERY; MARKER;

D O I：

10.1038/s41598-020-70252-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Controlling Nutritional Status (CON UT) score is a marker of nutrition and is associated with poor survival in various kinds of cancers. However, no reports have yet compared risk factors for colorectal cancer recurrence using a nutritional index. We assessed the predictive value of the CON UT score compared with the modified Glasgow Prognostic Score (mGPS) and Prognostic Nutritional Index (PNI) in colorectal cancer (CRC) patients. We performed a retrospective cohort study of the medical records of 336 consecutive patients with stage I-I I I CRC who underwent curative resection at a single institution in 2012-2017. Univariate and multivariate analyses were conducted to identify prognostic factors associated with relapse-free survival (RFS) and overall survival (OS). The low CONUT score group exhibited higher RFS and longer OS compared to the high CONUT score group (82.2% vs. 63.3%, p = 0.002 and 95.5% and 86.2%, p = 0.005, respectively). The Akaike's information criterion values of each index for RFS and OS were superior in CONUT score (723.71 and 315.46, respectively) compared to those of PNI (726.95 and 316.52) and mGPS (728.15 and 318.07, respectively). The CON UT score was found to be a good predictor of RFS and OS in patients with resectable CRC.

引用

页数：9

共 35 条

[1] NEW LOOK AT STATISTICAL-MODEL IDENTIFICATION [J].

AKAIKE, H .

IEEE TRANSACTIONS ON AUTOMATIC CONTROL, 1974, AC19 (06) :716-723

[2] Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer [J].

Allott, Emma H. ;

Masko, Elizabeth M. ;

Freedland, Alexis R. ;

Macias, Everardo ;

Pelton, Kristine ;

Solomon, Keith R. ;

Mostaghel, Elahe A. ;

Thomas, George, V ;

Pizzo, Salvatore, V ;

Freeman, Michael R. ;

Freedland, Stephen J. .

PROSTATE CANCER AND PROSTATIC DISEASES, 2018, 21 (02) :196-203

[3]

American Joint Committee on Cancer, 2018, AJCC CANC STAGING MA

[4] Nutritional effects on T-cell immunometabolism [J].

Cohen, Sivan ;

Danzaki, Keiko ;

MacIver, Nancie J. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2017, 47 (02) :225-235

[5] Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa [J].

Costa, Raquel G. F. ;

Caro, Paula L. ;

de Matos-Neto, Emidio M. ;

Lima, Joanna D. C. C. ;

Radloff, Katrin ;

Alves, Michele J. ;

Camargo, Rodolfo G. ;

Pessoa, Ana Flavia M. ;

Simoes, Estefania ;

Gama, Patricia ;

Cara, Denise C. ;

da Silva, Aloisio S. F. ;

Pereira, Welbert O. ;

Maximiano, Linda F. ;

de Alcantara, Paulo S. M. ;

Otoch, Jose P. ;

Trinchieri, Giorgio ;

Laviano, Alessandro ;

Muscaritoli, Maurizio ;

Seelaender, Marilia .

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2019, 10 (05) :1116-1127

[6] Prognostic factors in nonresectable pancreatic adenocarcinoma:: A rationale to design therapeutic trials [J].

Cubiella, J ;

Castells, A ;

Fondevila, C ;

Sans, M ;

Sabater, L ;

Navarro, S ;

Fernández-Cruz, L .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (05) :1271-1278

[7] Controlling Nutritional Status (CONUT) Score Is a Prognostic Marker in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy [J].

Daitoku, Nobuya ;

Miyamoto, Yuji ;

Tokunaga, Ryuma ;

Sakamoto, Yuki ;

Hiyoshi, Yukiharu ;

Iwatsuki, Masaaki ;

Baba, Yoshifumi ;

Iwagami, Shiro ;

Yoshida, Naoya ;

Baba, Hideo .

ANTICANCER RESEARCH, 2018, 38 (08) :4883-4888

[8] Nutritional screening; control of clinical undernutrition with analytical parameters [J].

de Ulibarri Perez, Jose Ignacio ;

Fernandez, Guillermo ;

Rodriguez Salvanes, Francisco ;

Diaz Lopez, Ana Maria .

NUTRICION HOSPITALARIA, 2014, 29 (04) :797-811

[9] Coagulation and cancer: biological and clinical aspects [J].

Falanga, A. ;

Marchetti, M. ;

Vignoli, A. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (02) :223-233

[10] Worldwide burden of colorectal cancer: a review [J].

Favoriti, Pasqualino ;

Carbone, Gabriele ;

Greco, Marco ;

Pirozzi, Felice ;

Pirozzi, Raffaele Emmanuele Maria ;

Corcione, Francesco .

UPDATES IN SURGERY, 2016, 68 (01) :7-11

← 1 2 3 4 →