[1] Ehime Univ, Sch Med, Dept Pharmacol Infomat Biomed, Toon, Ehime 7910295, Japan
[2] Ehime Univ, Integrated Ctr Sci, Toon, Ehime 7910295, Japan
[3] Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7910295, Japan
[4] Venture Business Lab, Matsuyama, Ehime 7910295, Japan
[5] Ehime Univ, Sch Med, Dept Internal Med 1, Toon, Ehime 7910295, Japan