Bactericidal/permeability increasing protein: A multifaceted protein with functions beyond LPS neutralization

被引：36

作者：

Balakrishnan, Arjun ^{[1
]}

Marathe, Sandhya A. ^{[1
]}

Joglekar, Madhura ^{[1
]}

Chakravortty, Dipshikha ^{[1
]}

机构：

[1] Indian Inst Sci, Ctr Infect Dis Res & Biosafety Labs, Dept Microbiol & Cell Biol, Bangalore 560012, Karnataka, India

来源：

INNATE IMMUNITY | 2013年 / 19卷 / 04期

关键词：

Bactericidal; permeability increasing protein (BPI); antimicrobial peptides; PLUNC proteins; endotoxic shock; Gram-negative bacteria; LIPOPOLYSACCHARIDE-BINDING-PROTEIN; INFLAMMATORY-BOWEL-DISEASE; POLYMORPHONUCLEAR LEUKOCYTE LYSOSOMES; CYTOPLASMIC ANTIBODIES ANCA; CYSTIC-FIBROSIS PATIENTS; HOST-DEFENSE FUNCTIONS; BPI-ANCA; PSEUDOMONAS-AERUGINOSA; INDUCED EXPRESSION; CATIONIC PROTEINS;

D O I：

10.1177/1753425912465098

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bactericidal permeability increasing protein (BPI), a 55-60kDa protein, first reported in 1975, has gone a long way as a protein with multifunctional roles. Its classical role in neutralizing endotoxin (LPS) raised high hopes among septic shock patients. Today, BPI is not just a LPS-neutralizing protein, but a protein with diverse functions. These functions can be as varied as inhibition of endothelial cell growth and inhibition of dendritic cell maturation, or as an anti-angiogenic, chemoattractant or opsonization agent. Though the literature available is extremely limited, it is fascinating to look into how BPI is gaining major importance as a signalling molecule. In this review, we briefly summarize the recent research focused on the multiple roles of BPI and its use as a therapeutic.

引用

页码：339 / 347

页数：9

共 88 条

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