LIVER-DAMAGE;
HUMAN LUNG;
DIFFERENTIATION;
CHEMOKINES;
RECEPTORS;
MEMORY;
PHENOTYPE;
D O I:
10.1016/j.humimm.2013.04.017
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Chronic systemic 'latent' viral infections such as Cytomegalovirus infection (CMV) are known to leave a fingerprint in the total T-cell population. We investigated whether chronic infections with a 'persistent' viremia, such as chronic hepatitis B and C (CHB, CHC), characterized by local organ-specific inflammation, also impact the total peripheral T-cell population or other virus specific T-cells that do not target hepatitis viruses. No phenotypic or functional differences were found between CD8(+) T-cells or CMV- or Epstein-Barr virus specific T-cells in viral hepatitis and healthy controls (HC). However, expression of chemokine-receptor CXCR3 was significantly higher on total peripheral CD8(+) T-cells of CHB or CHC patients compared to HC (p < 0.005) which may reflect the pervasive influence of a persistent viral infection, even when restricted to the liver. In CHB higher CXCR3 expression was associated with positive HBeAg-status and correlated with the percentage of HBsAg expressing hepatocytes found in liver biopsies, both pointing to a relation between CXCR3 expression and disease activity. In fact chemokine-receptors such as CXCR3 are important for T-cell recruitment to the liver and chemokine-ligands specific for CXCR3 are upregulated in chronic hepatitis. Modulating chemokine(receptor) expression could be a potential target for future therapy to optimize the anti-viral immunologic environment in the liver. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
机构:
Univ Hong Kong, Clin Trial Ctr, LKS Fac Med, Humanity & Hlth GI & Liver Clin,Unit 1309, Hong Kong, Hong Kong, Peoples R ChinaChang Gung Mem Hosp, Liver Res Unit, Taipei 105, Taiwan
Lau, George K. K.
Kao, Jia-Horng
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Hepatitis Res Ctr, Taipei 10016, TaiwanChang Gung Mem Hosp, Liver Res Unit, Taipei 105, Taiwan
Kao, Jia-Horng
Gane, Edward
论文数: 0引用数: 0
h-index: 0
机构:
Auckland City Hosp, New Zealand Liver Transplant Unit, Auckland 00142, New ZealandChang Gung Mem Hosp, Liver Res Unit, Taipei 105, Taiwan
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Oliviero, Barbara
Cerino, Antonella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Cerino, Antonella
论文数: 引用数:
h-index:
机构:
Varchetta, Stefania
Paudice, Enrica
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Paudice, Enrica
Pai, Somnath
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Pai, Somnath
Ludovisi, Serena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, Italy
Fdn IRCCS Policlin San Matteo, Dept Infect Dis, Div Infect Dis, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Ludovisi, Serena
Zaramella, Marco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, Italy
Fdn IRCCS Policlin San Matteo, Dept Infect Dis, Div Infect Dis, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Zaramella, Marco
Michelone, Giuseppe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, Italy
Fdn IRCCS Policlin San Matteo, Dept Infect Dis, Div Infect Dis, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Michelone, Giuseppe
Pugnale, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Viropathol Unit, Geneva, SwitzerlandFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Pugnale, Paolo
Negro, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Viropathol Unit, Geneva, SwitzerlandFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Negro, Francesco
Barnaba, Vincenzo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Internal Med, Fdn Andrea Cesalpino, Rome, Italy
Univ Roma La Sapienza, Ist Pasteur Cenci Bolognetti, Rome, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Barnaba, Vincenzo
Mondelli, Mario U.
论文数: 0引用数: 0
h-index: 0
机构:
Fdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
机构:
Univ Hong Kong, Clin Trial Ctr, LKS Fac Med, Humanity & Hlth GI & Liver Clin,Unit 1309, Hong Kong, Hong Kong, Peoples R ChinaChang Gung Mem Hosp, Liver Res Unit, Taipei 105, Taiwan
Lau, George K. K.
Kao, Jia-Horng
论文数: 0引用数: 0
h-index: 0
机构:
Natl Taiwan Univ Hosp, Hepatitis Res Ctr, Taipei 10016, TaiwanChang Gung Mem Hosp, Liver Res Unit, Taipei 105, Taiwan
Kao, Jia-Horng
Gane, Edward
论文数: 0引用数: 0
h-index: 0
机构:
Auckland City Hosp, New Zealand Liver Transplant Unit, Auckland 00142, New ZealandChang Gung Mem Hosp, Liver Res Unit, Taipei 105, Taiwan
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Oliviero, Barbara
Cerino, Antonella
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Cerino, Antonella
论文数: 引用数:
h-index:
机构:
Varchetta, Stefania
Paudice, Enrica
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Paudice, Enrica
Pai, Somnath
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Pai, Somnath
Ludovisi, Serena
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, Italy
Fdn IRCCS Policlin San Matteo, Dept Infect Dis, Div Infect Dis, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Ludovisi, Serena
Zaramella, Marco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, Italy
Fdn IRCCS Policlin San Matteo, Dept Infect Dis, Div Infect Dis, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Zaramella, Marco
Michelone, Giuseppe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pavia, I-27100 Pavia, Italy
Fdn IRCCS Policlin San Matteo, Dept Infect Dis, Div Infect Dis, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Michelone, Giuseppe
Pugnale, Paolo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Viropathol Unit, Geneva, SwitzerlandFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Pugnale, Paolo
Negro, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Viropathol Unit, Geneva, SwitzerlandFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Negro, Francesco
Barnaba, Vincenzo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Internal Med, Fdn Andrea Cesalpino, Rome, Italy
Univ Roma La Sapienza, Ist Pasteur Cenci Bolognetti, Rome, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Barnaba, Vincenzo
Mondelli, Mario U.
论文数: 0引用数: 0
h-index: 0
机构:
Fdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy
Univ Pavia, I-27100 Pavia, ItalyFdn IRCCS Policlin San Matteo, SC Infettivol Infettivol, Dipartimento Malattie Infett, Res Labs, I-27100 Pavia, Italy