Upregulation of CXCR3 expression on CD8+ T cells due to the pervasive influence of chronic hepatitis B and C virus infection

被引:12
作者
de Niet, A. [1 ,2 ]
de Bruijne, J. [1 ,2 ]
Plat-Sinnige, M. J. Tempelmans [1 ]
Takkenberg, R. B. [2 ]
van Lier, R. A. W. [3 ]
Reesink, H. W. [2 ]
van Leeuwen, E. M. M. [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands
[3] Sanquin Blood Supply, Amsterdam, Netherlands
关键词
LIVER-DAMAGE; HUMAN LUNG; DIFFERENTIATION; CHEMOKINES; RECEPTORS; MEMORY; PHENOTYPE;
D O I
10.1016/j.humimm.2013.04.017
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Chronic systemic 'latent' viral infections such as Cytomegalovirus infection (CMV) are known to leave a fingerprint in the total T-cell population. We investigated whether chronic infections with a 'persistent' viremia, such as chronic hepatitis B and C (CHB, CHC), characterized by local organ-specific inflammation, also impact the total peripheral T-cell population or other virus specific T-cells that do not target hepatitis viruses. No phenotypic or functional differences were found between CD8(+) T-cells or CMV- or Epstein-Barr virus specific T-cells in viral hepatitis and healthy controls (HC). However, expression of chemokine-receptor CXCR3 was significantly higher on total peripheral CD8(+) T-cells of CHB or CHC patients compared to HC (p < 0.005) which may reflect the pervasive influence of a persistent viral infection, even when restricted to the liver. In CHB higher CXCR3 expression was associated with positive HBeAg-status and correlated with the percentage of HBsAg expressing hepatocytes found in liver biopsies, both pointing to a relation between CXCR3 expression and disease activity. In fact chemokine-receptors such as CXCR3 are important for T-cell recruitment to the liver and chemokine-ligands specific for CXCR3 are upregulated in chronic hepatitis. Modulating chemokine(receptor) expression could be a potential target for future therapy to optimize the anti-viral immunologic environment in the liver. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:899 / 906
页数:8
相关论文
共 23 条
  • [11] Hepatitis B e Antigen Seroconversion: A Critical Event in Chronic Hepatitis B Virus Infection
    Liaw, Yun-Fan
    Lau, George K. K.
    Kao, Jia-Horng
    Gane, Edward
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (10) : 2727 - 2734
  • [12] Pervasive influence of hepatitis C virus on the phenotype of antiviral CD8+T cells
    Lucas, M
    Vargas-Cuero, AL
    Lauer, GM
    Barnes, E
    Willberg, CB
    Semmo, N
    Walker, BD
    Phillips, R
    Klenerman, P
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (03) : 1744 - 1753
  • [13] IFN-αβ and Self-MHC Divert CD8 T Cells into a Distinct Differentiation Pathway Characterized by Rapid Acquisition of Effector Functions
    Marshall, Heather D.
    Prince, Amanda L.
    Berg, Leslie J.
    Welsh, Raymond M.
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 185 (03) : 1419 - 1428
  • [14] Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections
    Oliviero, Barbara
    Cerino, Antonella
    Varchetta, Stefania
    Paudice, Enrica
    Pai, Somnath
    Ludovisi, Serena
    Zaramella, Marco
    Michelone, Giuseppe
    Pugnale, Paolo
    Negro, Francesco
    Barnaba, Vincenzo
    Mondelli, Mario U.
    [J]. JOURNAL OF HEPATOLOGY, 2011, 55 (01) : 53 - 60
  • [15] CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung
    Piet, Berber
    de Bree, Godelieve J.
    Smids-Dierdorp, Barbara S.
    van der Loos, Chris M.
    Remmerswaal, Ester B. M.
    von der Thusen, Jan H.
    van Haarst, Jan M. W.
    Eerenberg, Jan P.
    ten Brinke, Anja
    van der Bij, Wim
    Timens, Wim
    van Lier, Rene A. W.
    Jonkers, Rene E.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (06) : 2254 - 2263
  • [16] The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
    Qin, SX
    Rottman, JB
    Myers, P
    Kassam, N
    Weinblatt, M
    Loetscher, M
    Koch, AE
    Moser, B
    Mackay, CR
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (04) : 746 - 754
  • [17] Remmerswaal EB, 2011, BLOOD
  • [18] Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence
    Revie, Dennis
    Salahuddin, Syed Zaki
    [J]. VIROLOGY JOURNAL, 2011, 8
  • [19] Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells
    Rong, Qifei
    Huang, Jun
    Su, Enben
    Li, Jun
    Li, Jianyong
    Zhang, Lili
    Cao, Kejiang
    [J]. VIROLOGY JOURNAL, 2007, 4
  • [20] Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases
    Tacke, Frank
    Zimmermann, Henning W.
    Berres, Marie-Luise
    Trautwein, Christian
    Wasmuth, Hermann E.
    [J]. LIVER INTERNATIONAL, 2011, 31 (06) : 842 - 851