The mesenchymal transition subtype more responsive to dose dense taxane chemotherapy combined with carboplatin than to conventional taxane and carboplatin chemotherapy in high grade serous ovarian carcinoma: A survey of Japanese Gynecologic Oncology Group study (JGOG3016A1)

被引：15

作者：

Murakami, Ryusuke ^{[1
]}

Matsumura, Noriomi ^{[1
,2
]}

Michimae, Hirofumi ^{[3
]}

Tanabe, Hiroshi ^{[4
]}

Yunokawa, Mayu ^{[5
]}

Iwase, Haruko ^{[6
]}

Sasagawa, Motoi ^{[7
]}

Nakamura, Toshiaki ^{[8
]}

Tokuyama, Osamu ^{[9
]}

Takano, Masashi ^{[10
]}

Sugiyama, Toru ^{[11
]}

Sawasaki, Takashi ^{[12
]}

Isonishi, Seiji ^{[4
]}

Takehara, Kazuhiro ^{[13
]}

Nakai, Hidekatsu ^{[2
]}

Okamoto, Aikou ^{[4
]}

Mandai, Masaki ^{[1
,2
]}

Konishi, Ikuo ^{[1
,14
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Gynecol & Obstet, Kyoto, Japan

[2] Kindai Univ, Dept Obstet & Gynecol, Fac Med, Osaka, Japan

[3] Kitasato Univ, Sch Pharm, Dept Clin Med Biostat, Tokyo, Japan

[4] Jikei Univ, Dept Obstet & Gynecol, Sch Med, Tokyo, Japan

[5] Natl Canc Ctr, Dept Breast & Med Oncol, Tokyo, Japan

[6] Kitasato Univ, Dept Obstet & Gynecol, Sch Med, Sagamihara, Kanagawa, Japan

[7] Niigata Canc Ctr Hosp, Dept Gynecol, Niigata, Japan

[8] Kagoshima City Hosp, Dept Obstet & Gynecol, Kagoshima, Japan

[9] Osaka City Gen Hosp, Dept Gynecol, Osaka, Japan

[10] Natl Def Med Coll Hosp, Dept Obstet & Gynecol, Tokorozawa, Saitama, Japan

[11] Iwate Med Univ, Dept Obstet & Gynecol, Morioka, Iwate, Japan

[12] Natl Hosp Org, Kure Med Ctr, Dept Obstet & Gynecol, Hiroshima, Japan

[13] Natl Hosp Org Shikoku Canc Ctr, Dept Gynecol Oncol, Matsuyama, Ehime, Japan

[14] Natl Hosp Org Kyoto Med Ctr, Dept Obstet & Gynecol, Kyoto, Japan

来源：

GYNECOLOGIC ONCOLOGY | 2019年 / 153卷 / 02期

关键词：

Ovarian cancer; High grade serous ovarian carcinoma; Mesenchymal; Taxane sensitivity; Dose dense TC; NEOADJUVANT CHEMOTHERAPY; EPITHELIAL OVARIAN; MOLECULAR SUBTYPES; LUNG-CANCER; PACLITAXEL; EXPRESSION; SENSITIVITY; SURVIVAL; CLASSIFICATION; DISSEMINATION;

D O I：

10.1016/j.ygyno.2019.02.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. Recently, we established new histopathological subtypes of high-grade serous ovarian cancer (HGSOC) that include the mesenchymal transition (MT) type, the immune reactive (IR) type, the solid and proliferative (SP) type and the papillo-glandular (PG) type. Furthermore, we identified that the mesenchymal tran-scriptome subtype might be sensitive to taxane. We investigated whether these different histopathological subtypes of HGSOC require individualized chemotherapy for optimal treatment. Methods. We conducted the Japanese Gynecologic Oncology Group (JGOG) 3016A1 study, wherein we collected hematoxylin and eosin slides (total n = 201) and performed a histopathological analysis of patients with HGSOC registered in the JGOG3016 study, which compared the efficacy of conventional paclitaxel and carboplatin (TC) and dose-dense TC (ddTC). We analyzed the differences in progression-free survival (PFS) and overall survival (OS) among the four histopathological subtypes. We then compared the PFS between the TC group and the ddTC group for each histopathological subtype. Results. There were significant differences in both PFS and OS among the four histopathological subtypes (p = 0.001 and p < 0.001, respectively). Overall, the MT subtype had the shortest PFS (median 1.4 y) and OS (median 3.6 y). In addition, the MT subtype had a longer PFS in the ddTC group (median 1.8 y) than in the TC group (median 1.2 y) (p = 0.01). Conversely, the other types had no significant difference in PFS when the two regimens were compared. Conclusions. The MT type of HGSOC is sensitive to taxane; therefore, the ddTC regimen is recommended for this histopathological subtype. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：312 / 319

页数：8

共 39 条

[1] IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer [J].

Abiko, K. ;

Matsumura, N. ;

Hamanishi, J. ;

Horikawa, N. ;

Murakami, R. ;

Yamaguchi, K. ;

Yoshioka, Y. ;

Baba, T. ;

Konishi, I. ;

Mandai, M. .

BRITISH JOURNAL OF CANCER, 2015, 112 (09) :1501-1509

[2] PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction [J].

Abiko, Kaoru ;

Mandai, Masaki ;

Hamanishi, Junzo ;

Yoshioka, Yumiko ;

Matsumura, Noriomi ;

Baba, Tsukasa ;

Yamaguchi, Ken ;

Murakami, Ryusuke ;

Yamamoto, Ayaka ;

Kharma, Budiman ;

Kosaka, Kenzo ;

Konishi, Ikuo .

CLINICAL CANCER RESEARCH, 2013, 19 (06) :1363-1374

[3] The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel [J].

Ahmed, Ahmed Ashour ;

Mills, Anthony D. ;

Ibrahim, Ashraf E. K. ;

Temple, Jillian ;

Blenkiron, Cherie ;

Vias, Maria ;

Massie, Charlie E. ;

Iyer, N. Gopalakrishna ;

McGeoch, Adam ;

Crawford, Robin ;

Nicke, Barbara ;

Downward, Julian ;

Swanton, Charles ;

Bell, Stephen D. ;

Earl, Helena M. ;

Laskey, Ronald A. ;

Caldas, Carlos ;

Brenton, James D. .

CANCER CELL, 2007, 12 (06) :514-527

[4]

Ai B, 2016, AM J CANCER RES, V6, P1624

[5]

[Anonymous], ANN ONCOL S5

[6] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[7] Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer [J].

Bowtell, David D. ;

Boehm, Steffen ;

Ahmed, Ahmed A. ;

Aspuria, Paul-Joseph ;

Bast, Robert C., Jr. ;

Beral, Valerie ;

Berek, Jonathan S. ;

Birrer, Michael J. ;

Blagden, Sarah ;

Bookman, Michael A. ;

Brenton, James D. ;

Chiappinelli, Katherine B. ;

Martins, Filipe Correia ;

Coukos, George ;

Drapkin, Ronny ;

Edmondson, Richard ;

Fotopoulou, Christina ;

Gabra, Hani ;

Galon, Jerome ;

Gourley, Charlie ;

Heong, Valerie ;

Huntsman, David G. ;

Iwanicki, Marcin ;

Karlan, Beth Y. ;

Kaye, Allyson ;

Lengyel, Ernst ;

Levine, Douglas A. ;

Lu, Karen H. ;

McNeish, Iain A. ;

Menon, Usha ;

Narod, Steven A. ;

Nelson, Brad H. ;

Nephew, Kenneth P. ;

Pharoah, Paul ;

Powell, Daniel J., Jr. ;

Ramos, Pilar ;

Romero, Iris L. ;

Scott, Clare L. ;

Sood, Anil K. ;

Stronach, Euan A. ;

Balkwill, Frances R. .

NATURE REVIEWS CANCER, 2015, 15 (11) :668-679

[8] Japanese-US Common-Arm Analysis of Paclitaxel Plus Carboplatin in Advanced Non-Small-Cell Lung Cancer: A Model for Assessing Population-Related Pharmacogenomics [J].

Gandara, David R. ;

Kawaguchi, Tomoya ;

Crowley, John ;

Moon, James ;

Furuse, Kiyoyuki ;

Kawahara, Masaaki ;

Teramukai, Satoshi ;

Ohe, Yuichiro ;

Kubota, Kaoru ;

Williamson, Stephen K. ;

Gautschi, Oliver ;

Lenz, Heinz Josef ;

McLeod, Howard L. ;

Lara, Primo N., Jr. ;

Coltman, Charles Arthur, Jr. ;

Fukuoka, Masahiro ;

Saijo, Nagahiro ;

Fukushima, Masanori ;

Mack, Philip C. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (21) :3540-3546

[9] Influence of tumour micro-environment heterogeneity on therapeutic response [J].

Junttila, Melissa R. ;

de Sauvage, Frederic J. .

NATURE, 2013, 501 (7467) :346-354

[10]

Kajiyama H, 2007, INT J ONCOL, V31, P277

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