A nosocomial outbreak of Candida parapsilosis in southern Sweden verified by genotyping

被引：22
作者：
Brillowska-Dabrowska, Anna [3 ,4 ]
Schon, T. [6 ]
Pannanusorn, S. [1 ]
Lonnbro, N. [5 ]
Bernhoff, L. [6 ]
Bonnedal, J. [6 ]
Haggstrom, J. [2 ]
Wistedt, A. [6 ]
Fernandez, V. [1 ]
Arendrup, M. C. [3 ]
机构：
[1] Swedish Inst Infect Dis Control, Dept Parasitol Mycol & Environm Microbiol, Solna, Sweden
[2] Kalmar Cty Hosp, Dept Internal Med, Sect Haematol, S-39185 Kalmar, Sweden
[3] Statens Serum Inst, Unit Mycol & Parasitol, DK-2300 Copenhagen, Denmark
[4] Gdansk Univ Technol, Dept Microbiol, PL-80952 Gdansk, Poland
[5] Kalmar Cty Hosp, Dept Infect Dis, S-39185 Kalmar, Sweden
[6] Kalmar Cty Hosp, Dept Clin Microbiol & Hyg, S-39185 Kalmar, Sweden
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2009年 / 41卷 / 02期
关键词：
BLOOD-STREAM INFECTION; INTENSIVE-CARE-UNIT; SURVEILLANCE; FUNGEMIA; SUSCEPTIBILITY; EPIDEMIOLOGY; HANDS;
D O I：
10.1080/00365540802585301
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In a haematology ward, Candida parapsilosis was found in blood cultures from 4 patients within a month. As C. parapsilosis is known to have a restricted genetic diversity, a combined methodological approach was adopted to establish a possible epidemiological relationship among the isolates (n = 9). Multilocus sequence typing and random amplified polymorphic DNA analysis suggested a clonal origin of the isolates. The clonal origin was confirmed by microsatellite analysis, a method that displayed the highest discriminatory level and readily differentiated cluster isolates from 2 epidemiologically unrelated strains of C. parapsilosis. The use of novel methods of genotyping such as microsatellite analysis will facilitate epidemiological investigations of potential clonal outbreaks of fungaemia.
引用
收藏
页码：135 / 142
页数：8
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