The NLRP3 inflammasome and stroke

被引：3

作者：

Tong, Yeqing ^{[1
,2
]}

Ding, Zhi-Hong ^{[3
]}

Zhan, Fa-Xian ^{[1
]}

Cai, Li ^{[4
]}

Yin, Xiaoxv ^{[2
]}

Ling, Jin-Lian ^{[6
]}

Ye, Jian-Jun ^{[1
]}

Hou, Shuang-Yi ^{[1
]}

Lu, Zuxun ^{[2
]}

Wang, Zhi-Hong ^{[5
]}

Liu, Jia-Fa ^{[1
]}

机构：

[1] Hubei Ctr Dis Control & Prevent, Wuhan 430079, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Peoples R China

[3] Tradit Chinese Med Hosp, Xiangyang Hosp, Xiangyang 441021, Peoples R China

[4] Wuhan Ctr Dis Control & Prevent, Wuhan 430015, Peoples R China

[5] Shenzhen Univ, Dept Neurol, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Shenzhen 518035, Peoples R China

[6] Queens Univ Belfast, Belfast BT7 1NN, Antrim, North Ireland

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

NLRP3; inflammasome; inflammation; stroke; ISCHEMIC-STROKE; INTERLEUKIN-1-BETA INHIBITION; RISK-FACTOR; DISEASE; ATHEROSCLEROSIS; ACTIVATION; IL-1-BETA; SECRETION; INFECTION; CANAKINUMAB;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP. Among these receptors, NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome may activate the inflammation and participate in atherosclerosis, pathophysiology of myocardial infarction, resultin ischemia/reperfusion injury and stroke and other cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat stroke. In recent years, the role of inflammation in stroke has attracted much attention, and the in-depth study of its mechanism of action is gradually clear. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of stroke, which may supply some clues for future therapies and novel drug targets for stroke.

引用

页码：4787 / 4794

页数：8

共 68 条

[1] Guidelines for the early management of adults with ischemic stroke - A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the atherosclerotic peripheral vascular disease and quality of care outcomes in research interdisciplinary working groups [J].

Adams, Harold P., Jr. ;

del Zoppo, Gregory ;

Alberts, Mark J. ;

Bhatt, Deepak L. ;

Brass, Lawrence ;

Furlan, Anthony ;

Grubb, Robert L. ;

Higashida, Randall T. ;

Jauch, Edward C. ;

Kidwell, Chelsea ;

Lyden, Patrick D. ;

Morgenstern, Lewis B. ;

Qureshi, Adnan I. ;

Rosenwasser, Robert H. ;

Scott, Phillip A. ;

Wijdicks, Eelco F. M. .

STROKE, 2007, 38 (05) :1655-1711

[2]

Arenillas Juan F, 2005, Cerebrovasc Dis, V20 Suppl 2, P75, DOI 10.1159/000089359

[3]

Artlett Carol M, 2012, Open Rheumatol J, V6, P80, DOI 10.2174/1874312901206010080

[4] A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases [J].

Arulkumaran, Nishkantha ;

Unwin, Robert J. ;

Tam, Frederick W. K. .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2011, 20 (07) :897-915

[5] Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection [J].

Ataide, Marco A. ;

Andrade, Warrison A. ;

Zamboni, Dario S. ;

Wang, Donghai ;

Souza, Maria do Carmo ;

Franklin, Bernardo S. ;

Elian, Samir ;

Martins, Flaviano S. ;

Pereira, Dhelio ;

Reed, George ;

Fitzgerald, Katherine A. ;

Golenbock, Douglas T. ;

Gazzinelli, Ricardo T. .

PLOS PATHOGENS, 2014, 10 (01)

[6] ATHEROSCLEROSIS - BASIC MECHANISMS - OXIDATION, INFLAMMATION, AND GENETICS [J].

BERLINER, JA ;

NAVAB, M ;

FOGELMAN, AM ;

FRANK, JS ;

DEMER, LL ;

EDWARDS, PA ;

WATSON, AD ;

LUSIS, AJ .

CIRCULATION, 1995, 91 (09) :2488-2496

[7] Genetics of Common Polygenic Ischaemic Stroke: Current Understanding and Future Challenges [J].

Bevan, Steve ;

Markus, Hugh S. .

STROKE RESEARCH AND TREATMENT, 2011, 2011

[8]

Bitzur Rafael, 2005, Harefuah, V144, P647

[9] Acute infection as a risk factor for ischemic stroke [J].

Bova, IY ;

Bornstein, NM ;

Korczyn, AD .

STROKE, 1996, 27 (12) :2204-2206

[10] The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β [J].

Bracey, Nathan A. ;

Beck, Paul L. ;

Muruve, Daniel A. ;

Hirota, Simon A. ;

Guo, Jiqing ;

Jabagi, Habib ;

Wright, James R., Jr. ;

MacDonald, Justin A. ;

Lees-Miller, James P. ;

Roach, Daniel ;

Semeniuk, Lisa M. ;

Duff, Henry J. .

EXPERIMENTAL PHYSIOLOGY, 2013, 98 (02) :462-472

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