Pre-BCR signals and the control of Ig gene rearrangements

被引：56

作者：

Geier, JK ^{[1
]}

Schlissel, MS ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Div Immunol, Berkeley, CA 94720 USA

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 01期

关键词：

B cell development; pre-B cell receptor (pre-BCR); allelic exclusion; V(D)J recombination; transcriptional regulation;

D O I：

10.1016/j.smim.2005.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Progenitor B lymphocytes that successfully assemble a heavy chain gene encoding an immunoglobulin capable of pairing with surrogate light chain proteins trigger their own further differentiation by signaling via the pre-BCR complex. The pre-BCR signals several rounds of proliferation and, in this expanded population, directs a complex, B cell-specific set of epigenetic changes resulting in allelic exclusion of the heavy chain locus and activation of the light chain loci for V(D)J recombination. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：31 / 39

页数：9

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