Thrombosis of the cerebral veins and sinuses in acute promyelocytic leukemia after all-trans retinoic acid treatment: a case report

被引:7
作者
Ciccone, Maria [1 ]
Rigolin, Gian Matteo [1 ]
Viglione, Giulia Marta [1 ]
Borrelli, Massimo [2 ]
Serino, Maria Luisa [1 ]
Cuneo, Antonio [1 ]
机构
[1] Univ Ferrara, Dept Biomed Sci, Hematol Sect, I-44100 Ferrara, Italy
[2] St Anna Hosp, Neuroradiol Inst, Ferrara, Italy
关键词
acute promyelocytic leukemia; all-trans retinoic acid; cerebral thrombosis;
D O I
10.1097/MBC.0b013e3282fe7405
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thrombosis of the cerebral veins or sinuses is a rare cerebrovascular disorder, which seldom represents a complication of acute promyelocytic leukemia. To the best of our knowledge, it never occurred during treatment with all-trans retinoic acid. We report a case of a 35-year-old woman affected by acute promyelocytic leukemia, who developed massive thrombosis of the cerebral sinuses and veins when she was in complete morphological and molecular remission after all-trans retinoic acid and idarubicin treatment Anticoagulant therapy contributed to progressive dissolution of the thrombosis as documented by magnetic resonance imaging with complete disappearance of neurological signs without sequelae. Blood Coagul Fibrinolysis 19:721-723 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
引用
收藏
页码:721 / 723
页数:3
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