Urobiome in Gender-Related Diversities of Bladder Cancer

被引：22
作者：
Bilski, Konrad [1 ]
Dobruch, Jakub [1 ]
Kozikowski, Mieszko [1 ]
Skrzypczyk, Michal A. [1 ]
Oszczudlowski, Maciej [1 ]
Ostrowski, Jerzy [2 ]
机构：
[1] Independent Publ Hosp Prof W Orlowski, Ctr Postgrad Med Educ, Dept Urol, PL-00416 Warsaw, Poland
[2] Maria Sklodowska Curie Inst Oncol Ctr, Dept Genet, PL-02781 Warsaw, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 12期
关键词：
microbiome; bladder cancer; gender; REPRODUCTIVE FACTORS; MICROBIOME; INFECTIONS; RISK; CARCINOGENESIS; PATHOGENESIS; CONTRIBUTES; RESPONSES; HEALTH; TOOLS;
D O I：
10.3390/ijms21124488
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, another related concept which has been speculated to contribute to gender diversities in BC is the role of urinary pathogens in bladder carcinogenesis. Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that perturbation in the microbiome is associated with various human diseases. The aim of this review is to comprehensively analyze the current literature according to sex-related differences in the microbiome composition in BC.
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页码：1 / 13
页数：13
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