Densanins A and B, New Macrocyclic Pyrrole Alkaloids Isolated from the Marine Sponge Haliclona densaspicula

被引：23

作者：

Hwang, Buyng Su ^{[1
]}

Oh, Jung Soon ^{[1
]}

Jeong, Eun Ju ^{[3
]}

Sim, Chung J. ^{[2
]}

Rho, Jung-Rae ^{[1
]}

机构：

[1] Kunsan Natl Univ, Dept Oceanog, Jeonbuk 573701, South Korea

[2] Hannam Univ, Marine BioResources Bank, Taejon 306791, South Korea

[3] Gyeongnam Natl Univ Sci & Technol, Dept Agron & Med Plant Resources, Gyeongnam 660758, JinJu, South Korea

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 24期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1021/ol3028303

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC50 values of 1.05 and 2.14 mu M, respectively.

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收藏

页码：6154 / 6157

页数：4

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