Recent Clinical Trials in Atrial Fibrillation in Hypertensive Patients

被引：12

作者：

Manolis, Athanasios J. ^{[1
]}

Kallistratos, Manolis S. ^{[1
]}

Poulimenos, Leonidas E. ^{[1
]}

机构：

[1] Asklepe Gen Hosp, Dept Cardiol, Athens 16673, Greece

来源：

CURRENT HYPERTENSION REPORTS | 2012年 / 14卷 / 04期

关键词：

Hypertension; Atrial fibrillation; Anticoagulation treatment; RAS blockers; Apixaban; Dabigatran; Rivaroxaban; Eplerenone; CHADS(2) score; CHA(2)DS(2)-VASc score; HAS-BLED score; Vitamin K antagonists; Dronedarone; Vernakalant; CONVERTING ENZYME-INHIBITORS; RENIN-ANGIOTENSIN SYSTEM; II RECEPTOR BLOCKADE; HIGH-RISK; RHYTHM MANAGEMENT; STROKE; PREVENTION; ANTICOAGULATION; DABIGATRAN; ONSET;

D O I：

10.1007/s11906-012-0268-5

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Atrial Fibrillation (AF) is the most common clinically significant sustained cardiac arrhythmia, and Hypertension (HTN) is the most common cardiovascular disorder. AF is a major risk factor for strokes whether it is symptomatic or silent. Recent publications have shed light on the role of antihypertensive regiments in prevention of AF, while others have provided data on the efficacy and safety of novel antiarrhythmic drugs such as dronedarone and vernakalant. The older CHADS(2) score and its more refined modern counterparts are well validated to determine stroke risk and guide antithrombotic therapy, but haemorrhagic risk has to be respected as well, and scores such as HAS-BLED should be widely used. Novel classes of anticoagulants that overcome many of the drawbacks of warfarin have been introduced with promising results and pose new questions that need to be answered in the near future.

引用

页码：350 / 359

页数：10

共 51 条

[1] Apixaban with Antiplatelet Therapy after Acute Coronary Syndrome [J].

Alexander, John H. ;

Lopes, Renato D. ;

James, Stefan ;

Kilaru, Rakhi ;

He, Yaohua ;

Mohan, Puneet ;

Bhatt, Deepak L. ;

Goodman, Shaun ;

Verheugt, Freek W. ;

Flather, Marcus ;

Huber, Kurt ;

Liaw, Danny ;

Husted, Steen E. ;

Lopez-Sendon, Jose ;

De Caterina, Raffaele ;

Jansky, Petr ;

Darius, Harald ;

Vinereanu, Dragos ;

Cornel, Jan H. ;

Cools, Frank ;

Atar, Dan ;

Luis Leiva-Pons, Jose ;

Keltai, Matyas ;

Ogawa, Hisao ;

Pais, Prem ;

Parkhomenko, Alexander ;

Ruzyllo, Witold ;

Diaz, Rafael ;

White, Harvey ;

Ruda, Mikhail ;

Geraldes, Margarida ;

Lawrence, Jack ;

Harrington, Robert A. ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (08) :699-708

[2] Impact of atrial fibrillation on the risk of death [J].

Benjamin, EJ ;

Wolf, PA ;

D'Agostino, RB ;

Silbershatz, H ;

Kannel, WB ;

Levy, D .

CIRCULATION, 1998, 98 (10) :946-952

[3] INDEPENDENT RISK-FACTORS FOR ATRIAL-FIBRILLATION IN A POPULATION-BASED COHORT - THE FRAMINGHAM HEART-STUDY [J].

BENJAMIN, EJ ;

LEVY, D ;

VAZIRI, SM ;

DAGOSTINO, RB ;

BELANGER, AJ ;

WOLF, PA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (11) :840-844

[4] Patients Treated with Catheter Ablation for Atrial Fibrillation Have Long-Term Rates of Death, Stroke, and Dementia Similar to Patients Without Atrial Fibrillation [J].

Bunch, T. Jared ;

Crandall, Brian G. ;

Weiss, J. Peter ;

May, Heidi T. ;

Bair, Tami L. ;

Osborn, Jeffrey S. ;

Anderson, Jeffrey L. ;

Muhlestein, Joseph B. ;

Horne, Benjamin D. ;

Lappe, Donald L. ;

Day, John D. .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2011, 22 (08) :839-845

[5] Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia [J].

Bunch, T. Jared ;

Weiss, J. Peter ;

Crandall, Brian G. ;

May, Heidi T. ;

Bair, Tami L. ;

Osborn, Jeffrey S. ;

Anderson, Jeffrey L. ;

Muhlestein, Joseph B. ;

Horne, Benjamin D. ;

Lappe, Donald L. ;

Day, John D. .

HEART RHYTHM, 2010, 7 (04) :433-437

[6] A Randomized Active-Controlled Study Comparing the Efficacy and Safety of Vernakalant to Amiodarone in Recent-Onset Atrial Fibrillation [J].

Camm, A. John ;

Capucci, Alessandro ;

Hohnloser, Stefan H. ;

Torp-Pedersen, Christian ;

Van Gelder, Isabelle C. ;

Mangal, Brian ;

Beatch, Gregory .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (03) :313-321

[7]

Camm AJ, 2010, EUROPACE, V12, P1360, DOI [10.1093/europace/euq350, 10.1093/eurheartj/ehq278]

[8] Dronedarone in High-Risk Permanent Atrial Fibrillation [J].

Connolly, Stuart J. ;

Camm, A. John ;

Halperin, Jonathan L. ;

Joyner, Campbell ;

Alings, Marco ;

Amerena, John ;

Atar, Dan ;

Avezum, Alvaro ;

Blomstroem, Per ;

Borggrefe, Martin ;

Budaj, Andrzej ;

Chen, Shih-Ann ;

Ching, Chi Keong ;

Commerford, Patrick ;

Dans, Antonio ;

Davy, Jean-Marc ;

Delacretaz, Etienne ;

Di Pasquale, Giuseppe ;

Diaz, Rafael ;

Dorian, Paul ;

Flaker, Greg ;

Golitsyn, Sergey ;

Gonzalez-Hermosillo, Antonio ;

Granger, Christopher B. ;

Heidbuechel, Hein ;

Kautzner, Josef ;

Kim, June Soo ;

Lanas, Fernando ;

Lewis, Basil S. ;

Merino, Jose L. ;

Morillo, Carlos ;

Murin, Jan ;

Narasimhan, Calambur ;

Paolasso, Ernesto ;

Parkhomenko, Alexander ;

Peters, Nicholas S. ;

Sim, Kui-Hian ;

Stiles, Martin K. ;

Tanomsup, Supachai ;

Toivonen, Lauri ;

Tomcsanyi, Janos ;

Torp-Pedersen, Christian ;

Tse, Hung-Fat ;

Vardas, Panos ;

Vinereanu, Dragos ;

Xavier, Denis ;

Zhu, Jun ;

Zhu, Jun-Ren ;

Baret-Cormel, Lydie ;

Weinling, Estelle .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (24) :2268-2276

[9] Apixaban in Patients with Atrial Fibrillation [J].

Connolly, Stuart J. ;

Eikelboom, John ;

Joyner, Campbell ;

Diener, Hans-Christoph ;

Hart, Robert ;

Golitsyn, Sergey ;

Flaker, Greg ;

Avezum, Alvaro ;

Hohnloser, Stefan H. ;

Diaz, Rafael ;

Talajic, Mario ;

Zhu, Jun ;

Pais, Prem ;

Budaj, Andrzej ;

Parkhomenko, Alexander ;

Jansky, Petr ;

Commerford, Patrick ;

Tan, Ru San ;

Sim, Kui-Hian ;

Lewis, Basil S. ;

Van Mieghem, Walter ;

Lip, Gregory Y. H. ;

Kim, Jae Hyung ;

Lanas-Zanetti, Fernando ;

Gonzalez-Hermosillo, Antonio ;

Dans, Antonio L. ;

Munawar, Muhammad ;

O'Donnell, Martin ;

Lawrence, John ;

Lewis, Gayle ;

Afzal, Rizwan ;

Yusuf, Salim .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (09) :806-817

[10] Dabigatran versus Warfarin in Patients with Atrial Fibrillation. [J].

Connolly, Stuart J. ;

Ezekowitz, Michael D. ;

Yusuf, Salim ;

Eikelboom, John ;

Oldgren, Jonas ;

Parekh, Amit ;

Pogue, Janice ;

Reilly, Paul A. ;

Themeles, Ellison ;

Varrone, Jeanne ;

Wang, Susan ;

Alings, Marco ;

Xavier, Denis ;

Zhu, Jun ;

Diaz, Rafael ;

Lewis, Basil S. ;

Darius, Harald ;

Diener, Hans-Christoph ;

Joyner, Campbell D. ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (12) :1139-1151

← 1 2 3 4 5 6 →