Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses

被引：17

作者：

Figueroa, Horacio ^{[2
,3
,4
]}

Lozano, Mauricio ^{[1
]}

Suazo, Cristian ^{[1
]}

Eixarch, Elisenda ^{[5
,6
,7
]}

Illanes, Sebastian E. ^{[2
,3
,4
]}

Eduardo Carreno, Juan ^{[1
]}

Villanueva, Sandra ^{[1
]}

Hernandez-Andrade, Edgar ^{[5
,6
,7
]}

Gratacos, Eduard ^{[5
,6
,7
]}

Irarrazabal, Carlos E. ^{[1
]}

机构：

[1] Univ Los Andes, Mol Physiol Lab, Fac Med, Santiago 2200, Chile

[2] Univ Los Andes, Fac Med, Dept Obstet & Gynecol, Santiago 2200, Chile

[3] Univ Los Andes, Fac Med, Reprod Biol Lab, Santiago 2200, Chile

[4] Davila Clin, Dept Maternal Fetal Med, Santiago, Chile

[5] Hosp Clin Barcelona, Dept Maternal Fetal Med, ICGON, Barcelona, Spain

[6] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[7] CIBERER, Barcelona, Spain

来源：

EARLY HUMAN DEVELOPMENT | 2012年 / 88卷 / 11期

关键词：

IUGR; Rabbit; Inflammation; Hypoxia; Osmotic stress; GELATINASE-ASSOCIATED LIPOCALIN; FACTOR TONEBP/OREBP; BINDING PROTEIN; RENAL INJURY; FETAL-GROWTH; ADULT LIFE; HIGH NACL; ACTIVATION; DISEASE; RAT;

D O I：

10.1016/j.earlhumdev.2012.07.010

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of this work was to study the effect of intrauterine growth restriction (IUGR) on fetal kidneys. The IUGR was induced by uteroplacental vessels ligature in a model of pregnant rabbit. We centralized the study in the gene expression of essential proteins for fetal kidney development and kidney protection against hypoxia, osmotic stress, and kidney injury. The gene expression of HIF-1 alpha, NFAT5, IL-1 beta, NGAL, and ATM were studied by qRT-PCR and Western blot in kidneys from control and IUGR fetuses. Experimental IUGR fetuses were significantly smaller than the control animals (39 vs. 48 g, p<0.05). The number of glomeruli was decreased in IUGR kidneys, without morphological alterations. IUGR increased the gene expression of HIF-1 alpha, NFAT5, IL-1 beta, NGAL, and ATM (p<0.05) in kidneys of fetuses undergoing IUGR, suggesting that fetal blood flow restriction produce alterations in gene expression in fetal kidneys. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：899 / 904

页数：6

共 44 条

[1] Adverse effects of hyperglycemia on kidney development in rats -: In vivo and in vitro studies [J].

Amri, R ;

Freund, N ;

Vilar, J ;

Merlet-Bénichou, C ;

Lelièvre-Pégorier, M .

DIABETES, 1999, 48 (11) :2240-2245

[2] Both IL-1β and TNF-α Regulate NGAL Expression in Polymorphonuclear Granulocytes of Chronic Hemodialysis Patients [J].

Arena, Adriana ;

Stassi, Giovanna ;

Iannello, Daniela ;

Gazzara, Domenica ;

Calapai, Maria ;

Bisignano, Carlo ;

Bolignano, Davide ;

Lacquaniti, Antonio ;

Buemi, Michele .

MEDIATORS OF INFLAMMATION, 2010, 2010

[3] Clinical metabolomics and urinary NGAL for the early prediction of chronic kidney disease in healthy adults born ELBW [J].

Atzori, Luigi ;

Mussap, Michele ;

Noto, Antonio ;

Barberini, Luigi ;

Puddu, Melania ;

Coni, Elisabetta ;

Murgia, Federica ;

Lussu, Milena ;

Fanos, Vassilios .

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2011, 24 :41-44

[4] Fetal origins of adult disease:: strength of effects and biological basis [J].

Barker, DJP ;

Eriksson, JG ;

Forsén, T ;

Osmond, C .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2002, 31 (06) :1235-1239

[5] GROWTH IN-UTERO AND SERUM-CHOLESTEROL CONCENTRATIONS IN ADULT LIFE [J].

BARKER, DJP ;

MARTYN, CN ;

OSMOND, C ;

HALES, CN ;

FALL, CHD .

BRITISH MEDICAL JOURNAL, 1993, 307 (6918) :1524-1527

[6] Experimental intrauterine growth retardation alters renal development [J].

Bassan, H ;

Trejo, LL ;

Kariv, N ;

Bassan, M ;

Berger, E ;

Fattal, A ;

Gozes, I ;

Harel, S .

PEDIATRIC NEPHROLOGY, 2000, 15 (3-4) :192-195

[7] ATM Activation and Signaling under Hypoxic Conditions [J].

Bencokova, Zuzana ;

Kaufmann, Muriel R. ;

Pires, Isabel M. ;

Lecane, Philip S. ;

Giaccia, Amato J. ;

Hammond, Ester M. .

MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (02) :526-537

[8] Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction [J].

Bernstein, IM ;

Horbar, JD ;

Badger, GJ ;

Ohlsson, A ;

Golan, L .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2000, 182 (01) :198-206

[9] Nutritional and hormonal control of skeletal-muscle cell growth and differentiation [J].

Brameld, JM ;

Buttery, PJ ;

Dawson, JM ;

Harper, JMM .

PROCEEDINGS OF THE NUTRITION SOCIETY, 1998, 57 (02) :207-217

[10] Kidney gene expression analysis in a rat model of intrauterine growth restriction reveals massive alterations of coagulation genes [J].

Buffat, Christophe ;

Boubred, Farid ;

Mondon, Francoise ;

Chelbi, Sonia T. ;

Feuerstein, Jean-Marc ;

Lelievre-Pegorier, Martine ;

Vaiman, Daniel ;

Simeoni, Umberto .

ENDOCRINOLOGY, 2007, 148 (11) :5549-5557

← 1 2 3 4 5 →