Podocytes: Gaining a foothold

被引：33

作者：

Gart, Puneet ^{[3
]}

Holzman, Lawrence B. ^{[1
,2
]}

机构：

[1] Univ Penn, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA

[2] Dept Vet Affairs, Philadelphia, PA USA

[3] Univ Michigan, Div Nephrol, Ann Arbor, MI 48109 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2012年 / 318卷 / 09期

关键词：

Kidney; Podocyte; Intercellular junction; Cytoskeleton; Glomerulus; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; CONGENITAL NEPHROTIC SYNDROME; TOR SIGNALING NETWORK; ACTIN-BASED MOTILITY; TYROSINE PHOSPHORYLATION; ADHESION KINASE; DIABETIC-NEPHROPATHY; AFRICAN-AMERICANS; POLARITY PROTEIN; SLIT DIAPHRAGMS;

D O I：

10.1016/j.yexcr.2012.02.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In an attempt to understand the basis of glomerular disease, significant progress has been made in understanding the mechanisms that determine podocyte development and the maintenance of podocyte health. This review examines recent advances in this area focusing on the podocyte intercellular junction, actin cytoskeletal dynamics, and determinants of podocyte cell polarity, autophagy and mTOR biology. Published by Elsevier Inc.

引用

页码：955 / 963

页数：9

共 81 条

[1]

Akilesh S., 2011, J CLIN INVEST

[2] Motor Protein Myo1c Is a Podocyte Protein That Facilitates the Transport of Slit Diaphragm Protein Neph1 to the Podocyte Membrane [J].

Arif, E. ;

Wagner, M. C. ;

Johnstone, D. B. ;

Wong, H. N. ;

George, B. ;

Pruthi, P. A. ;

Lazzara, M. J. ;

Nihalani, D. .

MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (10) :2134-2150

[3] Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling [J].

Asanuma, K ;

Yanagida-Asanuma, E ;

Faul, C ;

Tomino, Y ;

Kim, K ;

Mundel, P .

NATURE CELL BIOLOGY, 2006, 8 (05) :485-U109

[4] Preferential adhesion mediated by Hibris and roughest regulates morphogenesis and patterning in the Drosophila eye [J].

Bao, SJ ;

Cagan, R .

DEVELOPMENTAL CELL, 2005, 8 (06) :925-935

[5] Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers [J].

Barletta, GM ;

Kovari, IA ;

Verma, RK ;

Kerjaschki, D ;

Holzman, LB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (21) :19266-19271

[6] A Role of Receptor Notch in Ligand cis-Inhibition in Drosophila [J].

Becam, Isabelle ;

Fiuza, Ulla-Maj ;

Arias, Alfonso Martinez ;

Milan, Marco .

CURRENT BIOLOGY, 2010, 20 (06) :554-560

[7] Phosphorylated YDXV motifs and nck SH2/SH3 adaptors act cooperatively to induce actin reorganization [J].

Blasutig, Ivan M. ;

New, Laura A. ;

Thanabalasuriar, Ajitha ;

Dayarathna, Thamara K. ;

Goudreault, Marilyn ;

Quaggin, Susan E. ;

Li, Shawn S. -C. ;

Gruenheid, Samantha ;

Jones, Nina ;

Pawson, Tony .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (06) :2035-2046

[8] Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis [J].

Brown, Elizabeth J. ;

Schloendorff, Johannes S. ;

Becker, Daniel J. ;

Tsukaguchi, Hiroyasu ;

Uscinski, Andrea L. ;

Higgs, Henry N. ;

Henderson, Joel M. ;

Pollak, Martin R. .

NATURE GENETICS, 2010, 42 (01) :72-U91

[9] Nck-independent actin assembly is mediated by two phosphorylated tyrosines within enteropathogenic Escherichia coli Tir [J].

Campellone, KG ;

Leong, JM .

MOLECULAR MICROBIOLOGY, 2005, 56 (02) :416-432

[10] Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C-elegans [J].

Chao, Daniel L. ;

Shen, Kang .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2008, 39 (02) :248-257

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