The article outlines a history of the concept of "disease-modifying antirheumatic drugs" or DMARDs-from the emergence in the 1970s of the idea of drugs with decisive long-term effects on bone erosion in rheumatoid arthritis (RA), through the consolidation and popularisation in the term DMARD in 1980s and 1990s. It then examines the usage of the terms "remission-inducing drugs" (RIDs) and "slow-acting anti-rheumatic drugs" (SAARDs), which for some years offered competition to the term DMARDs, thus underscoring the contingency of the establishment of DMARD as a word. Finally, it juxtaposes the apparently spontaneous emergence of the three terms DMARD, SAARD and RID, and the disappearance of the latter two, with a failed attempt in the early 1990s to replace these terms with the new term "disease-controlling antirheumatic treatment" (DC-ART). The analysis highlights the paradoxical qualities of the DMARD concept as robust albeit tension ridden, while playing down the role of identified individuals and overarching explanations of purpose.
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Univ Witwatersrand, Sch Physiol, Fac Hlth Sci, Exercise Lab, ZA-2001 Johannesburg, South AfricaUniv Witwatersrand, Sch Physiol, Fac Hlth Sci, Exercise Lab, ZA-2001 Johannesburg, South Africa
Prioreschi, Alessandra
Hodkinson, Bridget
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Univ Witwatersrand, Div Rheumatol, Dept Med, Chris Hani Baragwanath Acad Hosp,Fac Hlth Sci, ZA-2001 Johannesburg, South AfricaUniv Witwatersrand, Sch Physiol, Fac Hlth Sci, Exercise Lab, ZA-2001 Johannesburg, South Africa
Hodkinson, Bridget
Tikly, Mohammed
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Univ Witwatersrand, Div Rheumatol, Dept Med, Chris Hani Baragwanath Acad Hosp,Fac Hlth Sci, ZA-2001 Johannesburg, South AfricaUniv Witwatersrand, Sch Physiol, Fac Hlth Sci, Exercise Lab, ZA-2001 Johannesburg, South Africa
Tikly, Mohammed
McVeigh, Joanne A.
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Univ Witwatersrand, Sch Physiol, Fac Hlth Sci, Exercise Lab, ZA-2001 Johannesburg, South AfricaUniv Witwatersrand, Sch Physiol, Fac Hlth Sci, Exercise Lab, ZA-2001 Johannesburg, South Africa
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Univ Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
NIHR Leeds Muscoloskeletal Biomed Res Unit, Leeds Teaching Hosp NHS, Leeds, W Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Saleem, Benazir
Brown, Andrew K.
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Univ York, Hull & York Med Sch, York YO10 5DD, N Yorkshire, England
York Teaching Hosp NHS Fdn Trust, Dept Rheumatol, York, N Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Brown, Andrew K.
Quinn, Mark
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Univ York, Hull & York Med Sch, York YO10 5DD, N Yorkshire, England
York Teaching Hosp NHS Fdn Trust, Dept Rheumatol, York, N Yorkshire, England
Univ York, Hull York Med Sch, York YO10 5DD, N Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Quinn, Mark
Karim, Zunaid
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Univ Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
NIHR Leeds Muscoloskeletal Biomed Res Unit, Leeds Teaching Hosp NHS, Leeds, W Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Karim, Zunaid
Hensor, Elizabeth M. A.
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Univ Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
NIHR Leeds Muscoloskeletal Biomed Res Unit, Leeds Teaching Hosp NHS, Leeds, W Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Hensor, Elizabeth M. A.
Conaghan, Philip
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Univ Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
NIHR Leeds Muscoloskeletal Biomed Res Unit, Leeds Teaching Hosp NHS, Leeds, W Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Conaghan, Philip
Peterfy, Charles
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Synarc Inc, San Francisco, CA USAUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Peterfy, Charles
Wakefield, Richard J.
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Univ Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
NIHR Leeds Muscoloskeletal Biomed Res Unit, Leeds Teaching Hosp NHS, Leeds, W Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
Wakefield, Richard J.
Emery, Paul
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Univ Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England
NIHR Leeds Muscoloskeletal Biomed Res Unit, Leeds Teaching Hosp NHS, Leeds, W Yorkshire, EnglandUniv Leeds, Div Musculoskeletal Dis, Leeds LS2 9JT, W Yorkshire, England