Detection of Anaplastic Lymphoma Kinase (ALK) Gene Rearrangement in Non-Small Cell Lung Cancer and Related Issues in ALK Inhibitor Therapy A Literature Review

被引：0

作者：

Yi, Eunhee S. ^{[1
]}

Chung, Jin-Haeng ^{[2
]}

Kulig, Kimary ^{[3
]}

Kerr, Keith M. ^{[4
]}

机构：

[1] Mayo Clin, Div Anat Pathol, Dept Lab Med & Pathol, Rochester, MN 55902 USA

[2] Seoul Natl Univ, Dept Pathol, Bundang Hosp, Songnam, South Korea

[3] Natl Comprehens Canc Network, Ft Washington, MD USA

[4] Univ Aberdeen, Sch Med, Aberdeen Royal Infirm, Dept Pathol, Aberdeen AB9 2ZD, Scotland

来源：

MOLECULAR DIAGNOSIS & THERAPY | 2012年 / 16卷 / 03期

关键词：

EML4-ALK FUSION GENE; ADENOCARCINOMA; CRIZOTINIB; CLASSIFICATION; KIF5B-ALK; SURVIVAL; FEATURES; EGFR;

D O I：

10.1007/BF03262202

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Anaplastic lymphoma kinase (ALK) encodes a receptor tyrosine kinase, and ALK gene rearrangement (ALK+) is implicated in the oncogenesis of non-small cell lung carcinomas (NSCLCs), especially adenocarcinomas. The ALK inhibitor crizotinib was approved in August 2011 by the US Food and Drug Administration (FDA) for treating late-stage NSCLCs that are ALK+, with a companion fluorescent in situ hybridization (FISH) test using the Vysis ALK Break Apart FISH Probe Kit. This review covers pertinent issues in ALK testing, including approaches to select target patients for the test, pros and cons of different detection methods, and mechanisms as well as monitoring of acquired crizotinib resistance in ALK+ NSCLCs.

引用

页码：143 / 150

页数：8

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