Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models

被引：9
作者：
Flobak, Asmund [1 ,2 ]
Skanland, Sigrid S. [3 ,4 ]
Hovig, Eivind [5 ,6 ]
Tasken, Kjetil [3 ,4 ]
Russnes, Hege G. [7 ,8 ,9 ]
机构：
[1] St Olavs Univ Hosp, Canc Clin, Trondheim, Norway
[2] Norwegian Univ Norway, Dept Clin & Mol Med, Trondheim, Norway
[3] Oslo Univ Hosp, Inst Canc Res, Dept Canc Immunol, Oslo, Norway
[4] Univ Oslo, Inst Clin Med, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway
[5] Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway
[6] Univ Oslo, Ctr Bioinformat, Dept Informat, Oslo, Norway
[7] Oslo Univ Hosp, Dept Pathol, Oslo, Norway
[8] Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway
[9] Univ Oslo, Inst Clin Med, Oslo, Norway
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2022年 / 43卷 / 11期
关键词：
PATIENT-DERIVED ORGANOIDS; COLORECTAL-CANCER; TUMOR; BREAST;
D O I：
10.1016/j.tips.2022.08.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Functional precision medicine is a new, emerging area that can guide cancer treat-ment by capturing information from direct perturbations of tumor-derived, living cells, such as by drug sensitivity screening. Precision cancer medicine as currently implemented in clinical practice has been driven by genomics, and current molec-ular tumor boards rely extensively on genomic characterization to advise on thera-peutic interventions. However, genomic biomarkers can only guide treatment decisions for a fraction of the patients. In this review we provide an overview of the current state of functional precision medicine, highlight advances for drug -sensitivity screening enabled by cell culture models, and discuss how artificial intelligence (AI) can be coupled to functional precision medicine to guide patient stratification.
引用
收藏
页码：973 / 985
页数：13
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