Determinants of Insulin Resistance in Infants at Age 1 Year Impact of gestational diabetes mellitus

被引：18

作者：

Borgono, Carla A. ^{[2
]}

Hamilton, Jill K. ^{[3
]}

Ye, Chang ^{[1
]}

Hanley, Anthony J. ^{[1
,4
,5
]}

Connelly, Philip W. ^{[4
,6
]}

Sermer, Mathew ^{[7
]}

Zinman, Bernard ^{[1
,4
,8
]}

Retnakaran, Ravi ^{[1
,4
]}

机构：

[1] Mt Sinai Hosp, Leadership Sinai Ctr Diabet, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Div Gen Internal Med, Toronto, ON, Canada

[3] Hosp Sick Children, Dept Pediat, Toronto, ON M5G 1X8, Canada

[4] Univ Toronto, Div Endocrinol, Toronto, ON, Canada

[5] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada

[6] St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada

[7] Univ Toronto, Div Obstet & Gynecol, Toronto, ON, Canada

[8] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

来源：

DIABETES CARE | 2012年 / 35卷 / 08期

基金：

加拿大健康研究院;

关键词：

CATCH-UP GROWTH; GLUCOSE-TOLERANCE; SENSITIVITY; PREGNANCY; SECRETION; CHILDREN;

D O I：

10.2337/dc12-0173

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-The offspring of women with gestational diabetes mellitus (GDM) display a propensity for the early accrual of cardiometabolic risk factors, including insulin resistance, in childhood and adolescence. Thus, we sought to identify early life determinants of insulin resistance in infants of women with and without GDM. RESEARCH DESIGN AND METHODS-in total, 104 full-term, singleton infants born to women with (n = 36) and without (n = 68) GDM were evaluated at age 1 year, with insulin resistance assessed by homeostasis model (HOMA-IR). RESULTS-HOMA-IR at I year did not differ between infants born to mothers with and without GDM (P = 0.74). The sole independent predictor of infant HOMA-IR in the non-GDM group was birth weight (t = 3.33, P = 0.002). In contrast, weight gain in the 1st year was the only independent predictor of HOMA-IR in infants of women with GDM (t = 2.19, P = 0.039). CONCLUSIONS-In the 1st year of life, weight gain in infants born to women with GDM is associated with insulin resistance, unlike in their peers.

引用

页码：1795 / 1797

页数：3

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