Association of Interleukin-6-174 G>C Promoter Polymorphism with Increased Risk of Type 2 Diabetes Mellitus Patients with Diabetic Nephropathy in Turkey

被引：25
作者：
Karadeniz, Muammer [1 ]
Erdogan, Mehmet [2 ]
Berdeli, Afig [3 ]
Yilmaz, Candeger [2 ]
机构：
[1] Sifa Univ, Sch Med, Dept Endocrinol & Metab, TR-35100 Izmir, Turkey
[2] Ege Univ, Sch Med, Dept Endocrinol & Metab, Izmir, Turkey
[3] Ege Univ, Dept Pediat, Div Mol Med Lab, Izmir, Turkey
来源：
GENETIC TESTING AND MOLECULAR BIOMARKERS | 2014年 / 18卷 / 01期
关键词：
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; RELEASE INTERLEUKIN-6; MESANGIAL CELLS; GROWTH-FACTOR; END-PRODUCTS; MICROALBUMINURIA; SUSCEPTIBILITY; CAUCASIANS; LINKAGE; IL-6;
D O I：
10.1089/gtmb.2013.0357
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Objective: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in type 2 DN and control subjects. Materials and Methods: The patients selected from the Department of Endocrinology and Metabolism Diseases included 43 type 2 diabetes mellitus patients without DN and 43 type 2 diabetes mellitus patients with DN and 340 healthy normal controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, and insulin and Il-6 gene polymorphism genetic analysis. Results: IL-6 -174 G>C genotype distribution was different between the control group and the type 2 diabetes mellitus patients (p=0.004). The higher frequency of the polymorphic G allele was also similar for the group with type 2 diabetes mellitus as for the control group. The frequency of the polymorphic G allele was 83.9% in diabetic patients with nephropathy versus 70.9% in those without nephropathy (p=0.039). Conclusion: We suggest that the -174 G>C polymorphism of the IL-6 gene is an independent risk factor for DN in Turkish type 2 diabetes mellitus patients.
引用
收藏
页码：62 / 65
页数：4
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