Endothelial Cells in Allograft Rejection

被引：93

作者：

Al-Lamki, Rafia S. ^{[2
]}

Bradley, John R. ^{[2
]}

Pober, Jordan S. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, Sect Human & Translat Immunol, New Haven, CT 06520 USA

[2] Univ Cambridge, Addenbrookes Hosp, NIHR Cambridge Biomed Res Ctr, Dept Med, Cambridge CB2 1TN, England

来源：

TRANSPLANTATION | 2008年 / 86卷 / 10期

关键词：

Antigen presentation; Inflammation; Leukocyte; Lymphocyte; Antibody; Complement;

D O I：

10.1097/TP.0b013e3181891d8b

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

in organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection responses by presentation of alloantigen to circulating T cells; the development of inflammation and thrombosis; and as targets of injury and agents of repair.

引用

页码：1340 / 1348

页数：9

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