Synthesis and application of a chiral ionic liquid functionalized -cyclodextrin as a chiral selector in capillary electrophoresis

被引：44

作者：

Yu, Jia ^{[1
]}

Zuo, Lihua ^{[1
]}

Liu, Hongjiao ^{[1
]}

Zhang, Lijuan ^{[1
]}

Guo, Xingjie ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China

来源：

BIOMEDICAL CHROMATOGRAPHY | 2013年 / 27卷 / 08期

基金：

中国国家自然科学基金;

关键词：

chiral ionic liquid; capillary electrophoresis; enantioseparation; 6-O-2-hydroxpropyltrimethylammonium--cyclodextrin tetrafluoroborate; BETA-CYCLODEXTRIN; ENANTIOMERIC SEPARATION; BACKGROUND ELECTROLYTE; ENANTIOSEPARATION; CHROMATOGRAPHY; DERIVATIVES; PRODUCTS;

D O I：

10.1002/bmc.2900

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel chiral ionic liquid functionalized -cyclodextrin, 6-O-2-hydroxpropyltrimethylammonium--cyclodextrin tetrafluoroborate ([HPTMA--CD][BF4]), was synthesized and used as a chiral selector in capillary electrophoresis. [HPTMA--CD][BF4] not only increased the solubility in aqueous buffer in comparison with the parent compound, but also provided a stable reversal electroosmotic flow, and the enantioseparation of eight chiral drugs was examined in phosphate buffer containing [HPTMA--CD][BF4] as the chiral selector. The effects of the [HPTMA--CD][BF4] concentration and the background electrolyte pH were studied. Moreover, the chiral separation abilities of -CD and [HPTMA--CD][BF4] were compared and possible mechanisms for the chiral recognition of [HPTMA--CD][BF4] are discussed. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：1027 / 1033

页数：7

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