Radiation-induced Parotid Gland Atrophy in Patients with Head and Neck Cancer After Carbon-ion Radiotherapy

被引：6

作者：

Morikawa, Takamichi ^{[1
,2
,3
]}

Koto, Masashi ^{[1
,2
]}

Hasegawa, Azusa ^{[1
,2
]}

Takagi, Ryo ^{[1
,2
]}

Fujikawa, Akira ^{[1
,2
]}

Tsuji, Hiroshi ^{[1
,2
]}

Shibahara, Takahiko ^{[3
]}

Kamada, Tadashi ^{[1
,2
]}

机构：

[1] Natl Inst Radiol Sci Hosp, Natl Inst Quantum, Chiba, Japan

[2] Natl Inst Radiol Sci Hosp, Natl Inst Radiol Sci & Technol, Chiba, Japan

[3] Tokyo Dent Coll, Dept Oral & Maxillofacial Surg, Chiba, Japan

来源：

ANTICANCER RESEARCH | 2016年 / 36卷 / 10期

关键词：

Carbon-ion radiotherapy; parotid gland; dose-volume histogram; xerostomia; radiotherapy; THERAPY; IRRADIATION; XEROSTOMIA; RECOVERY; SYSTEM; CELL;

D O I：

10.21873/anticanres.11116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: This study aimed to clarify the relationship between dosimetric factors and parotid gland (PG) atrophy after carbon ion radiotherapy (C-ion RT). Patients and Methods: Fifty-four patients with head and neck tumours were enrolled and 93 irradiated PGs were analyzed. Thirty and 24 patients were treated with total doses [relative biological effectiveness (RBE)] of 57.6 Gy and 64.0 Gy, respectively, in 16 fractions. PG volumes were measured using computed tomographic images obtained before C-ion RT and every 3-6 months thereafter. Results: The median follow-up period was 46.4 months (range=24.0-123.0 months). Univariate analysis showed that PG volumes receiving more than 5, 10, 15, and 20 Gy RBE (V5, V10, V15 and V20, respectively), mean dose, and maximum dose were significantly associated with PG atrophy. Multivariate analysis indicated that only V5 was significantly associated with atrophy. Conclusion: Increasing V5 was a significant risk factor for PG atrophy after C-ion RT.

引用

页码：5403 / 5407

页数：5

共 19 条

[11] Evaluation of hybrid depth scanning for carbon-ion radiotherapy [J].

Inaniwa, Taku ;

Furukawa, Takuji ;

Kanematsu, Nobuyuki ;

Mori, Shinichiro ;

Mizushima, Kota ;

Sato, Shinji ;

Toshito, Toshiyuki ;

Shirai, Toshiyuki ;

Noda, Koji .

MEDICAL PHYSICS, 2012, 39 (05) :2820-2825

[12] Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy [J].

Kanai, T ;

Furusawa, Y ;

Fukutsu, K ;

Itsukaichi, H ;

EguchiKasai, K ;

Ohara, H .

RADIATION RESEARCH, 1997, 147 (01) :78-85

[13] Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy [J].

Kanai, T ;

Endo, M ;

Minohara, S ;

Miyahara, N ;

Koyama-Ito, H ;

Tomura, H ;

Matsufuji, N ;

Futami, Y ;

Fukumura, A ;

Hiraoka, T ;

Furusawa, Y ;

Ando, K ;

Suzuki, M ;

Soga, F ;

Kawachi, K .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1999, 44 (01) :201-210

[14] The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy [J].

Li, Yun ;

Taylor, Jeremy M. G. ;

Ten Haken, Randall K. ;

Eisbruch, Avraham .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 67 (03) :660-669

[15] Results of carbon ion radiotherapy for head and neck cancer [J].

Mizoe, Jun-etsu ;

Hasegawa, Azusa ;

Jingu, Keiichi ;

Takagi, Ryo ;

Bessyo, Hiroki ;

Morikawa, Takamichi ;

Tonoki, Mono ;

Tsuji, Hiroshi ;

Kamada, Tadashi ;

Tsujii, Hirohiko ;

Okamoto, Yoshitaka .

RADIOTHERAPY AND ONCOLOGY, 2012, 103 (01) :32-37

[16] Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial [J].

Nutting, Christopher M. ;

Morden, James P. ;

Harrington, Kevin J. ;

Urbano, Teresa Guerrero ;

Bhide, Shreerang A. ;

Clark, Catharine ;

Miles, Elizabeth A. ;

Miah, Aisha B. ;

Newbold, Kate ;

Tanay, MaryAnne ;

Adab, Fawzi ;

Jefferies, Sarah J. ;

Scrase, Christopher ;

Yap, Beng K. ;

A'Hern, Roger P. ;

Sydenham, Mark A. ;

Emson, Marie ;

Hall, Emma .

LANCET ONCOLOGY, 2011, 12 (02) :127-136

[17]

Sobin L, 2009, INT UNION CANC UICC

[18]

STEPHENS LC, 1986, RADIOTHER ONCOL, V7, P165

[19] Radiation-Induced Volume Changes in Parotid and Submandibular Glands in Patients with Head and Neck Cancer Receiving Postoperative Radiotherapy: A Longitudinal Study [J].

Wang, Zhong-He ;

Yan, Chao ;

Zhang, Zhi-Yuan ;

Zhang, Chen-Ping ;

Hu, Hai-Sheng ;

Kirwan, Jessica ;

Mendenhall, William M. .

LARYNGOSCOPE, 2009, 119 (10) :1966-1974

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