Radiation-induced Parotid Gland Atrophy in Patients with Head and Neck Cancer After Carbon-ion Radiotherapy

被引：6

作者：

Morikawa, Takamichi ^{[1
,2
,3
]}

Koto, Masashi ^{[1
,2
]}

Hasegawa, Azusa ^{[1
,2
]}

Takagi, Ryo ^{[1
,2
]}

Fujikawa, Akira ^{[1
,2
]}

Tsuji, Hiroshi ^{[1
,2
]}

Shibahara, Takahiko ^{[3
]}

Kamada, Tadashi ^{[1
,2
]}

机构：

[1] Natl Inst Radiol Sci Hosp, Natl Inst Quantum, Chiba, Japan

[2] Natl Inst Radiol Sci Hosp, Natl Inst Radiol Sci & Technol, Chiba, Japan

[3] Tokyo Dent Coll, Dept Oral & Maxillofacial Surg, Chiba, Japan

来源：

ANTICANCER RESEARCH | 2016年 / 36卷 / 10期

关键词：

Carbon-ion radiotherapy; parotid gland; dose-volume histogram; xerostomia; radiotherapy; THERAPY; IRRADIATION; XEROSTOMIA; RECOVERY; SYSTEM; CELL;

D O I：

10.21873/anticanres.11116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: This study aimed to clarify the relationship between dosimetric factors and parotid gland (PG) atrophy after carbon ion radiotherapy (C-ion RT). Patients and Methods: Fifty-four patients with head and neck tumours were enrolled and 93 irradiated PGs were analyzed. Thirty and 24 patients were treated with total doses [relative biological effectiveness (RBE)] of 57.6 Gy and 64.0 Gy, respectively, in 16 fractions. PG volumes were measured using computed tomographic images obtained before C-ion RT and every 3-6 months thereafter. Results: The median follow-up period was 46.4 months (range=24.0-123.0 months). Univariate analysis showed that PG volumes receiving more than 5, 10, 15, and 20 Gy RBE (V5, V10, V15 and V20, respectively), mean dose, and maximum dose were significantly associated with PG atrophy. Multivariate analysis indicated that only V5 was significantly associated with atrophy. Conclusion: Increasing V5 was a significant risk factor for PG atrophy after C-ion RT.

引用

页码：5403 / 5407

页数：5

共 19 条

[1] Dosimetric predictors of xerostomia for head-and-neck cancer patients treated with the SMART (simultaneous modulated accelerated radiation therapy) boost technique [J].

Amosson, CM ;

Teh, BS ;

Van, TJ ;

Uy, N ;

Huang, E ;

Mai, WY ;

Frolov, A ;

Woo, SY ;

Chiu, JK ;

Carpenter, LS ;

Lu, HH ;

Grant, WH ;

Butler, EB .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2003, 56 (01) :136-144

[2] Can dose reduction to one parotid gland prevent xerostomia? A feasibility study for locally advanced head and neck cancer patients treated with intensity-modulated radiotherapy [J].

Anand, A. K. ;

Jain, J. ;

Negi, P. S. ;

Chaudhoory, A. R. ;

Sinha, S. N. ;

Choudhury, P. S. ;

Kumar, R. ;

Munjal, R. K. .

CLINICAL ONCOLOGY, 2006, 18 (06) :497-504

[3] Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy [J].

Blanco, AI ;

Chao, KSC ;

El Naqa, I ;

Franklin, GE ;

Zakarian, K ;

Vicic, M ;

Deasy, JO .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 62 (04) :1055-1069

[4] LATE EFFECTS OF RADIATION-THERAPY IN THE HEAD AND NECK REGION [J].

COOPER, JS ;

FU, K ;

MARKS, J ;

SILVERMAN, S .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 31 (05) :1141-1164

[5] TOXICITY CRITERIA OF THE RADIATION-THERAPY ONCOLOGY GROUP (RTOG) AND THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER (EORTC) [J].

COX, JD ;

STETZ, J ;

PAJAK, TF .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 31 (05) :1341-1346

[6] RADIOTHERAPY DOSE-VOLUME EFFECTS ON SALIVARY GLAND FUNCTION [J].

Deasy, Joseph O. ;

Moiseenko, Vitali ;

Marks, Lawrence ;

Chao, K. S. Clifford ;

Nam, Jiho ;

Eisbruch, Avraham .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 76 (03) :S58-S63

[7] Parotid gland sparing in patients undergoing bilateral head and neck irradiation: Techniques and early results [J].

Eisbruch, A ;

Ship, JA ;

Martel, MK ;

TenHaken, RK ;

Marsh, LH ;

Wolf, GT ;

Esclamado, RM ;

Bradford, CR ;

Terrell, JE ;

Gebarski, SS ;

Lichter, AS .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 36 (02) :469-480

[8] Three-dimensional conformal radiotherapy (3D-CRT) versus intensity modulated radiation therapy (IMRT) in squamous cell carcinoma of the head and neck: A randomized controlled trial [J].

Gupta, Tejpal ;

Agarwal, JaiPrakash ;

Jain, Sandeep ;

Phurailatpam, Reena ;

Kannan, Sadhana ;

Ghosh-Laskar, Sarbani ;

Murthy, Vedang ;

Budrukkar, Ashwini ;

Dinshaw, Ketayun ;

Prabhash, Kumar ;

Chaturvedi, Pankaj ;

D'Cruz, Anil .

RADIOTHERAPY AND ONCOLOGY, 2012, 104 (03) :343-348

[9] Parotid gland-recovery after radiotherapy in the head and neck region-36 months follow-up of a prospective clinical study [J].

Hey, Jeremias ;

Setz, Juergen ;

Gerlach, Reinhard ;

Janich, Martin ;

Hildebrandt, Guido ;

Vordermark, Dirk ;

Gernhardt, Christian R. ;

Kuhnt, Thomas .

RADIATION ONCOLOGY, 2011, 6

[10] Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, Japan [J].

Inaniwa, Taku ;

Kanematsu, Nobuyuki ;

Matsufuji, Naruhiro ;

Kanai, Tatsuaki ;

Shirai, Toshiyuki ;

Noda, Koji ;

Tsuji, Hiroshi ;

Kamada, Tadashi ;

Tsujii, Hirohiko .

PHYSICS IN MEDICINE AND BIOLOGY, 2015, 60 (08) :3271-3286

← 1 2 →