DNA methylation inhibitors in cancer: Recent and future approaches

被引：176

作者：

Gros, Christina ^{[1
]}

Fahy, Jacques ^{[1
]}

Halby, Ludovic ^{[1
]}

Dufau, Isabelle ^{[1
]}

Erdmann, Alexandre ^{[1
]}

Gregoire, Jean-Marc ^{[1
]}

Ausseil, Frederic ^{[1
]}

Vispe, Stephane ^{[1
]}

Arimondo, Paola B. ^{[1
]}

机构：

[1] USR CNRS Pierre Fabre 3388 ETaC Epigenet Targetin, F-31035 Toulouse 01, France

来源：

BIOCHIMIE | 2012年 / 94卷 / 11期

关键词：

DNA methylation; Screening tests; DNMT inhibitors; Epigenetics; TUMOR-SUPPRESSOR GENES; AGENT 5-AZA-2'-DEOXYCYTIDINE DECITABINE; INTERFERENCE-MEDIATED KNOCKDOWN; HISTONE DEACETYLASE INHIBITORS; EMBRYONIC STEM-CELLS; NON-CPG METHYLATION; METHYLTRANSFERASE INHIBITORS; DE-NOVO; BREAST-CANCER; MYELODYSPLASTIC SYNDROME;

D O I：

10.1016/j.biochi.2012.07.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review presents the different human DNA methyltransferases (DNMTs), their biological roles, their mechanisms of action and their role in cancer. The description of assays for detecting DNMT inhibitors (DNMTi) follows. The different known DNMTi are reported along with their advantages, drawbacks and clinical trials. A discussion on the features of the future DNMT inhibitors will conclude this review. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：2280 / 2296

页数：17

共 225 条

[1] DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas [J].

Amara, Khaled ;

Ziadi, Sonia ;

Hachana, Mohamed ;

Soltani, Nabil ;

Korbi, Sadok ;

Trimeche, Mounir .

CANCER SCIENCE, 2010, 101 (07) :1722-1730

[2] Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy [J].

Amato, Robert J. .

CLINICAL GENITOURINARY CANCER, 2007, 5 (07) :422-426

[3]

[Anonymous], EPIGENETICS

[4]

[Anonymous], J MED CHEM

[5]

[Anonymous], P SBS C

[6]

[Anonymous], ANTIOXID REDOX SIGNA

[7]

[Anonymous], INFLAMM BOWEL DIS

[8]

[Anonymous], ONCOGENE

[9]

[Anonymous], J MED GENET

[10]

[Anonymous], ATHEROSCLEROSIS

← 1 2 3 4 5 6 7 8 9 10 →